Experimental copper deficiency, chromium deficiency and additional molybdenum supplementation in goats--pathological findings.
Experimental copper deficiency, chromium deficiency and additional molybdenum supplementation in goats--pathological findings.
复制标题
实验性铜缺乏，铬缺乏和山羊的额外补充 - 病理学发现。
DOI：
10.1186/1751-0147-42-311
复制
发表时间：
2001
影响因子：
2.1
通讯作者：
Frank, A
中科院分区：
文献类型：
--
作者：
Aupperle, H;Schoon, H A;Frank, A
继发性铜（Cu）缺乏、铬（Cr）缺乏和钼（Mo）缺乏被认为是导致瑞典西南部驼鹿“神秘”疾病的原因。本试验研究了半合成日粮中铜、铬缺乏对山羊临床、生化和病理学的影响。实验分为4组：对照组（n = 4）、铜缺乏组（n = 4）、铬缺乏组（n = 2）和铜+铬缺乏组（n = 3）。第3组在实验的最后2个月期间另外补充四硫代钼酸盐。第1组和第3组的主要组织病理学发现为肝脏病变，特征为重度活动性纤维化、胆管增生、含铁血黄素沉着症和轻度坏死。此外，第1组和第3组中外分泌胰腺的退行性改变显著。第3组的病变比第1组更明显。在第3组中，皮肤显示萎缩性皮肤病，而在第2组中，由念珠菌属引起的硬皮皮炎。观察了这项研究表明，肝脏，胰腺和皮肤主要受到长期缺乏铜的影响，钼的应用使这些发现变得复杂，而铬缺乏在我们的研究中没有产生组织形态学影响。
Secondary copper (Cu) deficiency, chromium (Cr) deficiency and molybdenosis (Mo) has been suggested to cause the "mysterious" moose disease in the southwest of Sweden. The present experiment was performed on goats to investigate the clinical, chemical, and pathological alterations after 20 months feeding of a semi-synthetic diet deficient in Cu and Cr. Four groups were included in the study: control group (n = 4), Cu-deficient group (group 1, n = 4), Cr-deficient group (group 2, n = 2) and Cu+Cr-deficient group (group 3, n = 3). Group 3 was additionally supplemented with tetrathiomolybdate during the last 2 months of the experiment. Main histopathological findings in groups 1 and 3 were the lesions in the liver, characterised by a severe active fibrosis, bile duct proliferation, haemosiderosis and mild necroses. Additionally, degenerative alterations of the exocrine pancreas were prominent in groups 1 and 3. Lesions in group 3 were more pronounced than in group 1. In group 3, the skin showed an atrophic dermatosis, while in group 2 a crusty dermatitis caused by Candida spp. was observed. This study shows that liver, pancreas and skin are mainly affected by a long term deficiency of copper and the findings are complicated by molybdenum application while chromium deficiency produced no histomorphological effects in our study.