Endogenous Opioids: Their Physiological Role and Receptors
Endogenous Opioids: Their Physiological Role and Receptors
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内源性阿片类药物：其生理作用和受体
DOI：
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
Shaik Rizwan
中科院分区：
文献类型：
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作者：
Anupama Koneru;S. Satyanarayana;Shaik Rizwan
2 摘要：内源性阿片系统包含大量阿片肽，它们是多种阿片受体的配体。内源性阿片肽的三个不同家族已得到充分表征：内啡肽、脑啡肽和强啡肽。最近，另外两种短肽 Endomorphin-1 和 Endomorphin-2 已被发现，它们对 µ 阿片受体具有高亲和力和选择性。内源性阿片肽与介导镇痛的三种主要阿片受体类型结合，分别称为 µ 和 。优选地，脑啡肽与受体相互作用，强啡肽与受体相互作用，内啡肽以相当的亲和力与μ和受体结合。
2 Abstract: The Endogenous Opioid system includes a large number of opioid peptides that are ligands for numerous types of opioid receptors. Three distinct families of endogenous opioid peptides have been well characterized-Endorphins, Enkephalins and Dynorphins. More recently, two additional short peptides, Endomorphin-1 and Endomorphin-2 that display a high affinity and selectivity for µ opioid receptors have been identified. The Endogenous opioid peptides bind to three primary opioid receptor types that mediate analgesia, designated µ, and . Preferentially, Enkephalins interact with the receptor, Dynorphins interact with the receptor and Endorphins bind to both µ and receptors with comparable affinity.