The Effect of Inhaled IFN-β on Worsening of Asthma Symptoms Caused by Viral Infections A Randomized Trial
The Effect of Inhaled IFN-β on Worsening of Asthma Symptoms Caused by Viral Infections A Randomized Trial
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DOI：
10.1164/rccm.201312-2235oc
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发表时间：
2014-07-15
影响因子：
24.7
通讯作者：
Monk, Phillip
中科院分区：
文献类型：
--
作者：
Djukanovic, Ratko;Harrison, Tim;Monk, Phillip
理论基础：在体外，哮喘患者的支气管上皮细胞更容易受到鼻病毒感染，这是由于缺乏诱导抗病毒蛋白干扰素-β造成的。目的：比较吸入β-干扰素和安慰剂预防或减轻呼吸道病毒引起的哮喘症状的有效性和安全性。方法：147例有病毒相关性加重史的哮喘患者，在出现感冒症状后24小时内随机分为吸入β-干扰素72例和安慰剂75例，并进行临床评估。收集相关样本以评估病毒感染和抗病毒反应。测量和主要结果：总共91%的随机患者患上了明确的感冒。在修改后的意向治疗人群中，哮喘症状在临床上没有明显恶化(哮喘控制六项问卷的平均变化
Rationale: Ex vivo, bronchial epithelial cells from people with asthma are more susceptible to rhinovirus infection caused by deficient induction of the antiviral protein, IFN-beta. Exogenous IFN-beta restores antiviral activity.Objectives: To compare the efficacy and safety of inhaled IFN-beta with placebo administered to people with asthma after onset of cold symptoms to prevent or attenuate asthma symptoms caused by respiratory viruses.Methods: A total of 147 people with asthma on inhaled corticosteroids (British Thoracic Society Steps 2-5), with a history of virus-associated exacerbations, were randomized to 14-day treatment with inhaled IFN-beta (n = 72) or placebo (n = 75) within 24 hours of developing cold symptoms and were assessed clinically, with relevant samples collected to assess virus infection and antiviral responses.Measurements and Main Results: A total of 91% of randomized patients developed a defined cold. In this modified intention-to-treat population, asthma symptoms did not get clinically significantly worse (mean change in six-item Asthma Control Questionnaire