TEMPORAL RESPONSE OF CIRCULATING METABOLITES AND HORMONES DURING SOMATOTROPIN TREATMENT OF GROWING PIGS
TEMPORAL RESPONSE OF CIRCULATING METABOLITES AND HORMONES DURING SOMATOTROPIN TREATMENT OF GROWING PIGS
复制标题
DOI：
10.2527/1992.701123x
复制
发表时间：
1992-01-01
影响因子：
3.3
通讯作者：
BELL, AW
中科院分区：
文献类型：
--
作者：
DUNSHEA, FR;BAUMAN, DE;BELL, AW
在每日i.m.注射猪生长激素（pST，120 μ g/kg BW）或赋形剂。 在第一次注射前24 h（d 0）开始采血（每1或2 h），并持续至d 2结束。 在给药第7天重复采样。 pST处理猪的采食量在第3天下降，在第7天下降31%（P <0.05）。 第一次注射pST后约3 h，血糖和血浆胰岛素浓度开始升高，在下次注射前几乎恢复到注射前水平。 到第2天结束时，循环中的葡萄糖和胰岛素水平高于pST治疗的猪比对照组。 在给药的每一天，注射后均观察到高血糖症和高胰岛素血症的时间模式。 虽然pST治疗没有长期增加基础血浆浓度的非酯化脂肪酸和甘油，这两种代谢产物表现出短暂的注射后升高，其幅度增加的治疗持续时间。 血浆尿素氮浓度在第一次注射pST后几小时内开始下降，到第7天，pST处理的猪的血浆尿素氮浓度降低了70%（P <0.01）。 一个模型，暗示PST诱导的外周组织胰岛素敏感性和（或）在所观察到的脂质和碳水化合物代谢的时间响应的响应性降低。
Temporal responses in the circulating concentrations of a number of intermediary metabolites and metabolic hormones were studied in chronically catheterized barrows (n = 4 per treatment) after either daily i.m. injection of porcine somatotropin (pST, 120-mu-g/kg of BW) or excipient. Blood sampling (every 1 or 2 h) began 24 h before the first injection (d 0) and continued until the end of d 2. Sampling was repeated on d 7 of treatment. Feed intake declined by d 3 in the pST-treated pigs and was 31% lower by d 7 of treatment (P < .05). Blood glucose and plasma insulin concentrations began to increase about 3 h after the first pST injection, almost returning to preinjection levels before the next injection. By the end of d 2, circulating levels of glucose and insulin were higher in pST-treated pigs than in the controls. A temporal pattern of hyperglycemia and hyperinsulinemia was observed postinjection on each day of treatment. Although pST treatment did not chronically increase basal plasma concentrations of nonesterified fatty acids and glycerol, both metabolites exhibited transient postinjection elevations, the magnitudes of which were augmented by duration of treatment. Plasma urea nitrogen concentrations began to decrease within a few hours after the first pST injection and by d 7 were 70% (P < .01) lower in the pST-treated pigs. A model is presented implicating pST-induced decreases in peripheral tissue insulin sensitivity and(or) responsiveness in the observed temporal responses in lipid and carbohydrate metabolism.