Peritubular capillary rarefaction: a new therapeutic target in chronic kidney disease.
Peritubular capillary rarefaction: a new therapeutic target in chronic kidney disease.
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DOI：
10.1007/s00467-013-2430-y
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发表时间：
2014-03
影响因子：
3
通讯作者：
Yamaguchi, Ikuyo
中科院分区：
文献类型：
--
作者：
Kida, Yujiro;Tchao, Bie Nga;Yamaguchi, Ikuyo
慢性肾脏病(CKD)在世界各地流行，迫切需要新的治疗方法。肾小管周围毛细血管(PTC)稀疏、间质纤维化和肾小管形态异常是CKD的主要特征之一，可预测CKD患者的肾脏预后。PTC内皮细胞(ECs)在慢性肾脏病过程中发生凋亡，导致毛细血管丢失、组织缺氧和氧化应激。虽然PTC稀疏的机制还不是很清楚，但PTC稀疏的过程依赖于CKD过程中发生的多个事件。这些导致血管生成环境不良的事件包括内皮细胞存活因子的丧失、血管生长抑制因子的产生增加、内皮细胞功能障碍、内皮祖细胞功能障碍以及周细胞脱离血管系统而导致的内皮细胞完整性的丧失。在这篇综述中，我们重点介绍了调控血管生成和EC存活的主要因素，并描述了这些因素在慢性肾脏病中PTC稀疏中的作用和可能的治疗应用。
Chronic kidney disease (CKD) is epidemic around the world and desparately needs new therapies. Peritubular capillary (PTC) rarefaction, along with interstitial fibrosis and tubular atorophy, is one of the major hallmarks of CKD and predicts renal outcome in patients with CKD. PTC endothelial cells (ECs) undergo apoptosis during CKD, leading to capillary loss, tissue hypoxia, and oxidant stress. Although the mechanisms of PTC rarefaction are not well understood, the process of PTC rarefaction depends on multiple events that happen during CKD. These events, which lead to an antiangiogenic environment, include deprivation of EC survival factors, increased production of vascular growth inhibitors, malfunction of ECs, dysfunction of endothelial progenitor cells, and loss of EC integrity via pericyte detachment from vasculature. In this review, we focus on major factors regulating angiogenesis and EC survival and describe roles of these factors in PTC rarefaction during CKD and possible therapeutic applications.
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DOI：
10.1152/ajprenal.00293.2005
发表时间：
2007-01-01
影响因子：
4.2
作者：
Burt, Laura E.;Forbes, Michael S.;Chevalier, Robert L.
通讯作者：
Chevalier, Robert L.
影响因子：
158.5
作者：
Eremina, Vera;Jefferson, J. Ashley;Quaggin, Susan E.
通讯作者：
Quaggin, Susan E.
分子机制和血管生成的临床应用。
影响因子：
64.8
作者：
Carmeliet, Peter;Jain, Rakesh K.
通讯作者：
Jain, Rakesh K.
影响因子：
2.5
作者：
Bellini, Maria H.;Coutinho, Enia L.;Schor, Nestor
通讯作者：
Schor, Nestor
DOI：
10.1152/ajprenal.00294.2005
发表时间：
2007-01-01
影响因子：
4.2
作者：
Burt, Laura E.;Forbes, Michael S.;Chevalier, Robert L.
通讯作者：
Chevalier, Robert L.