Revisiting mechanisms and functions of prenatal hormone-mediated maternal effects using avian species as a model
Revisiting mechanisms and functions of prenatal hormone-mediated maternal effects using avian species as a model
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DOI：
10.1098/rstb.2018.0115
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发表时间：
2019-04-15
影响因子：
6.3
通讯作者：
Tschirren, Barbara
中科院分区：
文献类型：
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作者：
Groothuis, Ton G. G.;Hsu, Bin-Yan;Tschirren, Barbara
在多变但可预测的环境中，母体效应可以自适应地调节后代的发育轨迹。激素合成对环境因素敏感，因此母体激素是将环境线索传递给下一代的强大机制。鸟类已成为研究胚胎介导的母体效应的关键模型，因为胚胎在母体外发育，便于测量和操纵产前激素暴露。与此同时，鸟类是整合近因和最终途径的优秀模型，这是更好地理解鸟类介导的母体效应进化的关键。在过去的二十年里，大量的研究表明，越来越多的差异是由妊娠介导的母体效应引起的。在这篇综述中，我们讨论了环境，遗传因素和社会相互作用在导致这些差异中的作用，并提供了一个框架来解决这些问题。我们还探讨了在很大程度上被忽视的作用，胚胎在调节母体信号，以及成本和收益的激素转移和表达的不同家庭成员。最后，我们强调了富有成效的途径，为未来的研究，已经开辟了感谢新的理论见解和技术进步的领域。这篇文章是主题问题的一部分“发展差异：早期生命的影响和进化医学”。
Maternal effects can adaptively modulate offspring developmental trajectories in variable but predictable environments. Hormone synthesis is sensitive to environmental factors, and maternal hormones are thus a powerful mechanism to transfer environmental cues to the next generation. Birds have become a key model for the study of hormone-mediated maternal effects because the embryo develops outside the mother's body, facilitating the measurement and manipulation of prenatal hormone exposure. At the same time, birds are excellent models for the integration of both proximate and ultimate approaches, which is key to a better understanding of the evolution of hormone-mediated maternal effects. Over the past two decades, a surge of studies on hormone-mediated maternal effects has revealed an increasing number of discrepancies. In this review, we discuss the role of the environment, genetic factors and social interactions in causing these discrepancies and provide a framework to resolve them. We also explore the largely neglected role of the embryo in modulating the maternal signal, as well as costs and benefits of hormone transfer and expression for the different family members. We conclude by highlighting fruitful avenues for future research that have opened up thanks to new theoretical insights and technical advances in the field.This article is part of the theme issue 'Developing differences: early-life effects and evolutionary medicine'.