Epidemiology of Symptomatic Chiari Malformation in Tatarstan: Regional and Ethnic Differences in Prevalence
Epidemiology of Symptomatic Chiari Malformation in Tatarstan: Regional and Ethnic Differences in Prevalence
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DOI：
10.1093/neuros/nyy175
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发表时间：
2019-05-01
期刊：
影响因子：
4.8
通讯作者：
Heiss, John D.
中科院分区：
文献类型：
--
作者：
Bogdanov, Enver I.;Faizutdinova, Aisylu T.;Heiss, John D.
背景技术背景：流行病学可以评估基亚里I畸形（CM 1）对人群神经系统健康的影响，并评估影响CM 1发展的因素。目的：分析CM1.METHODS患病率的区域和种族差异：在俄罗斯联邦鞑靼斯坦共和国（RT）的人口进行了评估，患者CM 1症状超过11年的时间。868例患者出现典型的CM 1症状。从神经系统检查和磁共振成像（MRI）测量后颅窝structures的数据进行了analyzed.Results：MRI证据CM 1，定义为小脑扁桃体躺在至少5毫米低于枕骨大孔，发现在67%的有症状的患者。另外33%有症状的患者扁桃体异位2 - 4 mm，我们将其定义为“边缘性基亚里畸形1型（bCM 1）”。“在整个RT中，症状性CM 1的周期患病率为20：100 000; bCM 1为10：100 000; CM 1和bCM 1一起为30：100 000。与CM 1症状的患者的患病率是更大的北方比南部地区的鞑靼斯坦共和国，由于高患病率（413：100 000）的CM 1在Baltimore地区的一个北方districtions.CONCLUSION：三分之一的典型症状的CM 1的患者有不到5毫米的扁桃体异位（bCM 1）。CM 1型症状对患者人群健康影响的评估应包括bCM 1患者组。在RT的Balkiran地区发现了一个基亚里畸形患者的区域性疾病集群，需要进一步研究。
BACKGROUND: Epidemiology can assess the effect of Chiari I malformation (CM1) on the neurological health of a population and evaluate factors influencing CM1 development.OBJECTIVE: To analyze the regional and ethnic differences in the prevalence of CM1.METHODS: The population of the Republic of Tatarstan (RT) in the Russian Federation was evaluated for patients with CM1 symptoms over an 11-yr period. Typical symptoms of CM1 were found in 868 patients. Data from neurological examination and magnetic resonance imaging (MRI) measurement of posterior cranial fossa structures were analyzed.RESULTS: MRI evidence of CM1, defined as cerebellar tonsils lying at least 5 mm inferior to the foramen magnum, was found in 67% of symptomatic patients. Another 33% of symptomatic patients had 2 to 4 mm of tonsillar ectopia, which we defined as "borderline Chiari malformation type 1 (bCM1)." The period prevalence in the entire RT for symptomatic CM1 was 20:100 000; for bCM1 was 10:100 000; and for CM1 and bCM1 together was 30:100 000. Prevalence of patients with CM1 symptoms was greater in the northern than southern districts of Tatarstan, due to a high prevalence (413:100 000) of CM1 in the Baltasy region in one of the northern districts.CONCLUSION: One-third of patients with typical symptoms of CM1 had less than 5 mm of tonsillar ectopia (bCM1). Assessments of the health impact of CM1-type symptoms on a patient population should include the bCM1 patient group. A regional disease cluster of patients with Chiari malformation was found in Baltasy district of RT and needs further study.