EFFECT OF RACE ON EXPRESSION OF ACQUIRED IMMUNODEFICIENCY SYNDROME-ASSOCIATED NEPHROPATHY
EFFECT OF RACE ON EXPRESSION OF ACQUIRED IMMUNODEFICIENCY SYNDROME-ASSOCIATED NEPHROPATHY
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DOI：
10.1001/archinte.151.1.125
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发表时间：
1991-01-01
影响因子：
--
通讯作者：
BOSCH, JP
中科院分区：
文献类型：
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作者：
CANTOR, ES;KIMMEL, PL;BOSCH, JP
与获得性免疫缺陷综合征（艾滋病）相关的肾脏疾病的患病率尚不清楚，但在不同地区似乎有所不同。纽约、纽约州和佛罗里达州迈阿密的研究中心都曾报道过艾滋病并发肾病的患者。这些人群包括很大比例的黑人患者和静脉注射吸毒者。来自加州旧金山的报告显示，肾脏疾病合并艾滋病的患病率很低，但人口主要由白人患者组成，滥用药物的比例很低。乔治华盛顿大学医学中心是华盛顿特区31.4%艾滋病患者的治疗地点。这个人群大致平均分为黑人和白人患者。对艾滋病和肾病患者的回顾性调查显示，大约三分之二的患者是黑人，这反映了艾滋病患者的人口结构；11%的患者静脉注射药物滥用是导致艾滋病发展的危险因素；74%有急性肾功能衰竭。在这些病人中，黑人和白人的比例大致相等。26%的人口患有慢性肾衰竭，但绝大多数是黑人。急性肾功能衰竭和慢性肾功能衰竭患者的年龄、性别、种族、危险因素等比例均无差异，但黑人和白人慢性肾功能衰竭患者的比例有显著差异。造成这些差异的原因尚不清楚，但这些人群中宿主对病毒蛋白的反应、生理适应或社会经济因素的差异可能在调节个别患者肾脏疾病的表达中发挥重要作用。
The prevalence of renal disease associated with the acquired immunodeficiency syndrome (AIDS) is unknown, but appears to vary in different regions. Centers in New York, NY, and Miami, Fla, have reported patients with renal disease complicating AIDS. These populations have included large proportions of black patients and intravenous drug abusers. Reports from San Francisco, Calif, have suggested the prevalence of renal disease complicating AIDS is low, but the population was composed primarily of white patients, with a low proportion of drug abusers. The George Washington University Medical Center was the site of treatment for 31.4% of the patients with AIDS in Washington, DC. This population was split roughly evenly between black and white patients. A retrospective survey of patients with both AIDS and renal disease revealed approximately two thirds of the patients were black, reflecting the demographics of the population with AIDS; 11% of patients had intravenous drug abuse as a risk factor for the development of AIDS; and 74% had acute renal failure. Of these patients, approximately equal proportions were black and white. Twenty-six percent of the population had chronic renal failure, but the overwhelming proportion were black. There were no differences between proportions of patients in age, sex, race, or risk factors in patients with acute renal failure and chronic renal failure, but there was a significant difference in the proportions of black and white patients with chronic renal failure. The reason for these differences is unknown, but differences in host responses to viral proteins, physiologic adaptations, or socioeconomic factors in these populations may play an important role in mediating the expression of renal disease in individual patients.