Family history of pre-eclampsia as a predictor for pre-eclampsia in primigravidas
Family history of pre-eclampsia as a predictor for pre-eclampsia in primigravidas
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DOI：
10.1016/s0020-7292(97)00241-5
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发表时间：
1998-01-01
影响因子：
3.8
通讯作者：
Brennecke, SP
中科院分区：
文献类型：
--
作者：
Cincotta, RB;Brennecke, SP
目的：评估先兆子痫家族史知识作为先兆子痫发生的预测因子的临床效用。方法：前瞻性研究368例产科教学医院门诊的初产妇。从妇女那里获得任何先兆子痫家族史的详细信息，并观察其随后的产科结局。结果：368例初产妇中，34例（9.2%）发生子痫前期。总组中有18名（4.9%）妇女表示，她们的母亲（12名）、姐妹（5名）或两者（1名）患有先兆子痫。在这18名妇女中，5名（27.8%）发展为先兆子痫。在无家族史的妇女中，29例（8.3%）发生先兆子痫（相对危险度，RR = 3.4; 95%CI，1.5-7.6; P = 0.018）。有阳性家族史的妇女中有4名（22.2%）发展为重度先兆子痫，而有阴性家族史的妇女中有18名（5.1%）发展为重度先兆子痫（RR = 4.3; 95%CI，1.6-11.5; P = 0.017）。结论：在妊娠晚期，先兆子痫家族史与重度先兆子痫风险增加4倍相关。这一临床病史确定了一组在妊娠期间需要密切临床监测的人群，他们可能适合进行预防性干预试验。(C)1998年国际妇产科联合会。
Objective: To assess the clinical utility of knowledge of a family history of pre-eclampsia as a predictor for the development of pre-eclampsia in primigravid women. Methods: 368 primigravid women were prospectively recruited from the outpatients department of an obstetric teaching hospital. Details of any family history of pre-eclampsia were obtained from the women and their subsequent obstetric outcomes were observed. Results: Of 368 primigravid women, 34 (9.2%) developed pre-eclampsia. Eighteen (4.9%) women of the total group stated that they had a mother (12), sister (five) or both (one) who had had pre-eclampsia. Of these 18 women, five (27.8%) developed pre-eclampsia. Of the women who had no family history, 29 (8.3%) developed pre-eclampsia (relative risk, RR = 3.4; 95% CI, 1.5-7.6; P = 0.018). Four (22.2%) of the women with a positive family history developed severe pre-eclampsia compared to 18 (5.1%) with a negative family history (RR = 4.3; 95% CI, 1.6-11.5; P = 0.017). Conclusions: In a primigravida, a family history of pre-eclampsia is associated with a fourfold increased risk of severe pre-eclampsia. This clinical history identifies a group who warrant close clinical surveillance during pregnancy and who may be suitable for trials of prophylactic interventions. (C) 1998 International Federation of Gynecology and Obstetrics.