The superior colliculus-pretectum mediates the direct effects of light on sleep
The superior colliculus-pretectum mediates the direct effects of light on sleep
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DOI：
10.1073/pnas.95.15.8957
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发表时间：
1998-07-21
影响因子：
11.1
通讯作者：
Benca, RM
中科院分区：
文献类型：
--
作者：
Miller, AM;Obermeyer, WH;Benca, RM
光和暗对哺乳动物的睡眠和觉醒有直接的影响，但这些影响背后的神经机制却知之甚少。在白化病大鼠中进行视觉皮层或上级丘-顶盖前区的损伤，以确定介导光对行为的影响的视网膜受体区域，包括由关灯触发的快速眼动睡眠和短光暗周期中非快速眼动睡眠的重新分配。急性反应的变化，在光条件下几乎消除了上级丘-顶盖前区病变，但不是视觉皮层病变。昼夜节律的夹带是明显的病变组和正常对照组。因此，急性光暗对睡眠和觉醒的影响似乎是独立于皮层视觉或昼夜节律介导的。
Light and dark have immediate effects on sleep and wakefulness in mammals, but the neural mechanisms underlying these effects are poorly understood. Lesions of the visual cortex or the superior colliculus-pretectal area were performed in albino rats to determine retinorecipient areas that mediate the effects of light on behavior, including rapid eye movement sleep triggering by lights-off and redistribution of non-rapid eye movement sleep in short light-dark cycles. Acute responses to changes in light conditions were virtually eliminated by superior colliculus-pretectal area lesions but not by visual cortex lesions. Circadian entrainment was evident in both groups with lesions and in normal controls. Thus, acute light-dark effects on sleep and wakefulness appear to be mediated independently from cortical vision or circadian rhythms.