Osteosarcomagenesis: modeling cancer initiation in the mouse.
Osteosarcomagenesis: modeling cancer initiation in the mouse.
复制标题
作者：
Jones KB
骨肉瘤仍然是一种致命的恶性肿瘤折磨青少年和年轻人。已确定的骨肉瘤中缺乏前体细胞和存在广泛的遗传变异，使得对其起源的研究变得困难。许多候选假设已经在小鼠中进行了测试，小鼠是一种骨肉瘤背景发病率较高的物种。化学致癌物、外部射线辐射和趋骨重金属放射性同位素都已被证明是野生型小鼠的骨肉瘤致源。许多癌基因，通过整合病毒引入或从遗传基因位点异常激活，参与并可以单独驱动骨肉瘤的发生。生殖系和条件基因消融的形式，但不是所有的非整倍体诱导基因，传统的肿瘤抑制剂，和因子，在间充质分化的正常功能，也被证明骨肉瘤comagenic，特别是在组合沉默Rb 1和p53通路。本文回顾了小鼠模型的丰富历史，他们告诉我们关于人类疾病，以及未来的小鼠实验还承诺教。
Osteosarcoma remains a deadly malignancy afflicting adolescents and young adults. The lack of a precursor and the panoply of genetic aberrations present in identified osteosarcomas makes study of its initiation difficult. A number of candidate hypotheses have been tested in the mouse, a species with a higher background incidence of osteosarcoma. Chemical carcinogens, external beam radiation, and bone-seeking heavy metal radioisotopes have all proven to be osteosarcomagenic in wild-type mice. A number of oncogenes, introduced via integrating viruses or aberrantly activated from heritable genetic loci, participate in and can individually drive osteosarcomagenesis. Germline and conditional gene ablations in the form of some but not all aneuploidy-inducing genes, conventional tumor suppressors, and factors that function normally in mesenchymal differentiation have also proven osteosarcomagenic, especially in combinations that silence the Rb1 and p53 pathways. This paper reviews the rich history of mouse models of osteosarcomagenesis, what they have taught us about the human disease, and what future mouse experiments yet promise to teach.
登录
查看更多内容
影响因子：
2.5
作者：
Deitel, K;Dantzer, D;Bell, R
通讯作者：
Bell, R
DOI：
10.1073/pnas.0805462105
发表时间：
2008-08-19
影响因子：
11.1
作者：
Berman, Seth D.;Calo, Eliezer;Lees, Jacqueline A.
通讯作者：
Lees, Jacqueline A.
影响因子：
4.2
作者：
Alves de Oliveira, Elisangela Claudia;Szejnfeld, Vera Lucia;de Moura Castro, Charlles Heldan
通讯作者：
de Moura Castro, Charlles Heldan
DOI：
10.1083/jcb.200507081
发表时间：
2006-02-13
期刊：
The Journal of cell biology
影响因子：
--
作者：
Baker DJ;Jeganathan KB;Malureanu L;Perez-Terzic C;Terzic A;van Deursen JM
通讯作者：
van Deursen JM
影响因子：
5.4
作者：
Donovan, Stacy L.;Schweers, Brett;Dyer, Michael A.
通讯作者：
Dyer, Michael A.