EFFECTS OF CAFFEINE AND L-PHENYLISOPROPYLADENOSINE ON LOCOMOTOR-ACTIVITY OF MICE
EFFECTS OF CAFFEINE AND L-PHENYLISOPROPYLADENOSINE ON LOCOMOTOR-ACTIVITY OF MICE
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DOI：
10.1016/0091-3057(87)90211-5
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发表时间：
1987-10-01
影响因子：
3.6
通讯作者：
MIDDAUGH, LD
中科院分区：
文献类型：
--
作者：
BUCKHOLTZ, NS;MIDDAUGH, LD
使用C57 BL/6 J和DBA/2 J小鼠来确定对咖啡因的行为反应的可能差异是否可能与A1腺苷受体的差异有关，根据品系而不同。虽然它们对咖啡因的反应不同，但菌株对A1腺苷激动剂L-苯基异丙基腺苷（PIA）的反应没有差异，也没有对A1激动剂[3 H]N6-环己基腺苷（CHA）在不同脑区的结合反应不同。因此，对咖啡因反应的行为差异不能用腺苷结合的差异来解释。在替代机制中，A2受体的菌株差异似乎是最有希望的。
C57BL/6J and DBA/2J mice were used to determine if possible differences in the behavioral response to caffeine might be related to differences in A1 adenosine receptors, differed according to strain. Although their response to caffeine differed, the strains did not differ in response to the A1 adenosine agonist L-phenylisopropyladenosine (PIA) nor in the binding of the A1 agonist [3H]N6-cyclohexyladenosine (CHA) in various brain regions. Thus, the behavioral differences in response to caffeine could not be accounted for by differences in adenosine binding. Of alternative mechanisms, strain differences in A2 receptors appear to be the most promising.