Respiratory Microbial Co-infection With SARS-CoV-2
Respiratory Microbial Co-infection With SARS-CoV-2
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DOI：
10.3389/fmicb.2020.02079
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发表时间：
2020-08-25
影响因子：
5.2
通讯作者：
Meltzer, Herbert Y.
中科院分区：
文献类型：
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作者：
Massey, Bill W.;Jayathilake, Karuna;Meltzer, Herbert Y.
与其他病原体的共同感染是流行病的一个众所周知的特征。我们确定了2020年3月和4月接受SARS-CoV-2感染检测的12075名美国受试者中各种呼吸道病原体的患病率和类型。其他呼吸道病原体的感染本身至少会产生一些SARS-CoV-2症状，包括死亡，这些感染在SARS-CoV-2 +和SARS-CoV-2-受试者中都存在。非SARS-CoV-2感染率在SARS-CoV-2 +组（86%）明显高于SARS-CoV-2-组（76%）（p< 0.0001）。在两个受试者组中存在的共病原体中有ek。pneumoniaeandM。白内障可自行产生严重的呼吸道疾病，高龄和养老院状况与较高的SARS-CoV-2 +和合并感染率相关。未来检测共病原体的存在将有助于在当前大流行中诊断和最佳治疗疑似SARS-CoV-2呼吸道感染。
Co-infection with additional pathogens is a well-known feature of pandemics. We determined the prevalence and type of a wide variety of respiratory pathogens in 12,075 United States subjects tested for SARS-CoV-2 infection in March and April 2020. Infections with other respiratory pathogens, which on their own produce at least some SARS-CoV-2 symptoms including mortality, were present in both SARS-CoV-2 + and SARS-CoV-2- subjects. Non-SARS-CoV-2 infection rates were significantly higher in SARS-CoV-2 + (86%) patients than SARS-CoV-2- patients (76%) (p< 0.0001). Among the co-pathogens present in both subject groups wereK. pneumoniaeandM. catarrhaliswhich can produce serious respiratory illness on their own, Advanced age and nursing home status were associated with higher SARS-CoV-2 + and co-infection rates. Testing for the presence of co-pathogens going forward will assist in the diagnosis and optimal treatment of suspected SARS-CoV-2 respiratory infections in the current pandemic.