A combined [11C]diprenorphine PET study and fMRI study of acupuncture analgesia
A combined [11C]diprenorphine PET study and fMRI study of acupuncture analgesia
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DOI：
10.1016/j.bbr.2008.04.020
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发表时间：
2008-11-03
影响因子：
2.7
通讯作者：
Gollub, Randy L.
中科院分区：
文献类型：
--
作者：
Dougherty, Darin D.;Kong, Jian;Gollub, Randy L.
功能性神经影像学研究表明，大脑的外侧网络与疼痛感知的感觉方面有关，而内侧网络与情感方面有关。阿片受体的最高浓度是在内侧网络。有重要证据表明，内源性阿片类药物对疼痛和镇痛的体验至关重要。我们在针灸过程中应用了综合多模态成像方法。我们发现眼窝前额皮质、脑岛和脑桥的功能性磁共振成像信号发生变化，[11C]二丙诺啡正电子发射断层扫描信号在眼窝前额皮质、内侧前额皮质、脑岛、丘脑和前扣带皮层发生变化。这些发现包括外侧和内侧疼痛网络内的大脑区域。(C) 2008 Elsevier B.V.版权所有
Functional neuroimaging Studies Suggest that a lateral network in the brain is associated with the Sensory aspects of pain perception while a medial network is associated with affective aspects. The highest concentration of opioid receptors is in the medial network. There is significant evidence that endogenous opioids are central to the experience of pain and analgesia. We applied an integrative multimodal imaging approach during acupuncture. We found functional magnetic resonance imaging signal changes in the orbitofrontal cortex, insula, and pons and [11C]diprenorphine positron emission tomography signal changes in the orbitofrontal cortex, medial prefrontal cortex, insula, thalamus, and anterior cingulate cortex. These findings include brain regions within both the lateral and medial pain networks. (C) 2008 Elsevier B.V. All rights reserved.