Two-dimensional strain imaging of controlled rabbit hearts.
Two-dimensional strain imaging of controlled rabbit hearts.
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DOI：
10.1016/j.ultrasmedbio.2009.04.007
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发表时间：
2009-09
影响因子：
2.9
通讯作者：
O'Donnell, Matthew
中科院分区：
文献类型：
--
作者：
Jia, Congxian;Olafsson, Ragnar;Kim, Kang;Kolias, Theodore J.;Rubin, Jonathan M.;Weitzel, William F.;Witte, Russell S.;Huang, Sheng-Wen;Richards, Michael S.;Deng, Cheri X.;O'Donnell, Matthew
超声应变成像采用二维（2-D）斑点跟踪已被提出定量评估心肌收缩力的变化，由于缺血。作为常规临床应用的一步，它的性能必须在受控模型系统中得到证明。在这项研究中，我们开发了一种控制良好的二维心脏弹性成像技术，使用两个共面和正交的线性探针同时对离体兔心脏进行成像。左前降支结扎术引起急性缺血。兴奋-收缩解耦剂2,3-丁二酮单肟以4mM浓度施用，可可逆地降低心肌收缩力。单探头结果显示，平面内主变形轴的方向变化可以帮助定位LAD结扎引起的膨出区域，与相应的Evans Blue染色吻合良好，基于主拉伸的应变或应变大小可以表征心肌收缩性。使用不对称位移精度（即，正常的单探头测量具有良好的轴向，但较差的横向估计）的这两个发现进一步验证了使用对称位移精度（即，双探头测量仅使用准确的轴向跟踪估计）。然而，由于横向位移估计差异很大，使用单个探头进行二维心脏应变成像的准确性取决于探头的方向。
Ultrasound strain imaging using two-dimensional (2-D) speckle tracking has been proposed to quantitatively assess changes in myocardial contractility due to ischemia. Its performance must be demonstrated in a controlled model system as a step toward routine clinical application. In this study, a well-controlled 2-D cardiac elasticity imaging technique was developed using two coplanar and orthogonal linear probes simultaneously imaging an isolated retroperfused rabbit heart. Acute ischemia was generated by left anterior descending (LAD) artery ligation. An excitation-contraction decoupler, 2,3-butanedione monoxime, was applied at a 4mM concentration to reversibly reduce myocardial contractility. Results using a single probe demonstrate that directional changes in the in-plane principal deformation axes can help locate the bulging area due to LAD ligation, which matched well with corresponding Evans Blue staining, and strains, or strain magnitude, based on principal stretches can characterize heart muscle contractility. These two findings using asymmetric displacement accuracy (i.e., normal single probe measurements with good axial but poor lateral estimates) were further validated using symmetric displacement accuracy (i.e., dual probe measurements using only accurate axial tracking estimates from each). However, the accuracy of 2-D cardiac strain imaging using a single probe depends on the probe’s orientation due to the large variance in lateral displacement estimates.
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影响因子：
20.1
作者：
AKAISHI, M;WEINTRAUB, WS;HELFANT, RH
通讯作者：
HELFANT, RH
影响因子：
39.3
作者：
Hanekom, Lizelle;Cho, Goo-Yeong;Marwick, Thomas H.
通讯作者：
Marwick, Thomas H.
影响因子：
37.8
作者：
HEGER, JJ;WEYMAN, AE;FEIGENBAUM, H
通讯作者：
FEIGENBAUM, H
影响因子：
2.9
作者：
Matre, K;Ahmed, AB;Heimdal, A
通讯作者：
Heimdal, A
影响因子：
10.6
作者：
Maurice, RL;Bertrand, R
通讯作者：
Bertrand, R