Treating Individuals 5 - Treatment with drugs to lower blood pressure and blood cholesterol based on an individual's absolute cardiovascular risk
Treating Individuals 5 - Treatment with drugs to lower blood pressure and blood cholesterol based on an individual's absolute cardiovascular risk
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DOI：
10.1016/s0140-6736(05)17833-7
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发表时间：
2005-01-01
期刊：
影响因子：
168.9
通讯作者：
Rodgers, A
中科院分区：
文献类型：
--
作者：
Jackson, R;Lawes, CMM;Rodgers, A
在这篇综述中，我们概述了针对绝对心血管风险高的患者进行降低血压和血胆固醇药物治疗的原理，无论其血压或血胆固醇水平如何。由于血压和胆固醇的特定水平在与其他风险因素隔离考虑时几乎没有临床意义，因此高血压或高胆固醇血症等术语的价值有限。血压和血胆固醇升高的单独管理指南需要被综合心血管风险管理指南所取代，并且应该常规使用绝对心血管风险预测评分。由于心血管风险因素相互作用，适度减少几个风险因素可能比减少一个风险因素更有效。一个负担得起的每日药丸结合低剂量的各种药物可能是有用的许多人与轻微异常的心血管危险因素。
In this review, we outline the rationale for targeting blood pressure and blood cholesterol lowering drug treatments to patients at high absolute cardiovascular risk, irrespective of their blood pressure or blood cholesterol levels. Because the specific levels of blood pressure and cholesterol are of little clinical relevance when considered in isolation from other risk factors, terms such as hypertension or hypercholesterolaemia have limited value. Separate management guidelines for raised blood pressure and blood cholesterol need to be replaced by integrated cardiovascular risk management guidelines, and absolute cardiovascular risk prediction scores should be used routinely. Since cardiovascular risk factors interact with each other, moderate reductions in several risk factors can be more effective than major reductions in one. An affordable daily pill combining low doses of various drugs could be useful for the many individuals with slightly abnormal cardiovascular risk factors.