Multicolorful Carbon Dots for Tumor Theranostics.
Multicolorful Carbon Dots for Tumor Theranostics.
复制标题
DOI：
10.2174/0929867324666170316110810
复制
发表时间：
2017-03
影响因子：
4.1
通讯作者：
Haitao Wang;Jingran Bi;B. Zhu;M. Tan
中科院分区：
文献类型：
--
作者：
Haitao Wang;Jingran Bi;B. Zhu;M. Tan
癌症是全世界人类健康的巨大威胁，这是由于恶性细胞在整个身体中的不可控制的扩散。准确的诊断和靶向治疗方法是癌症治疗的关键因素。在单一纳米载体中组合治疗剂和诊断剂能够同时监测癌症进展并以最小的副作用调整疾病治疗。目的碳量子点是一类一维尺寸小于10 nm的新型荧光碳纳米结构，具有优良的光学性能、较大的比表面积和低毒性。碳量子点的独特性质使其成为在一个递送系统中掺入癌症靶向部分、生物成像剂和抗肿瘤剂的理想载体。方法利用Web of Science进行文献检索，查找与碳量子点和肿瘤治疗诊断学相关的文章。结果在过去的10年里，碳量子点在癌症治疗诊断学中的应用已经被报道了很多。本文简要介绍了碳量子点的发展历史和基本荧光性质，重点讨论了碳量子点的合成策略及其在生物成像、靶向抗癌药物输送、光动力学治疗、光热治疗以及肿瘤治疗诊断学中的基因输送等方面的应用。还强调了碳量子点在癌症治疗诊断学中的未来方向。
BACKGROUND Cancer is a great threat of human health worldwide due to the uncontrollable spread of malignant cells throughout the body. Accurate diagnosis and targeted therapy approaches are critical factors for cancer treatment. Combination of therapeutic and diagnostic agents in a single nanocarrier enables to simultaneously monitor the cancer progression and tune disease therapy with minimum side effect. OBJECTIVE Carbon dots are a novel class of small fluorescence carbon nanostructures with size less than 10 nm at least in one dimension, which exhibit excellent optical properties, larger surface area to volume ratio and low toxicity. The unique properties of carbon dots make it as an ideal carrier for incorporation of cancer targeting moieties, bio-imaging agents and antineoplastic agents in one delivery system. METHODS An literature search was conducted using Web of Science to find out articles related to carbon dots and tumor theranostics. RESULTS Numerous applications of carbon dots in cancer theranostics have been reported during the past 10 years. This review introduces a brief history and basic fluorescent properties of carbon dots, and then discusses synthesis strategies and applications of carbon dots in biological imaging, targeted anti-cancer drug delivery, photodynamic therapy, photothermal therapy as well as gene delivery for cancer theranostics. Future directions of carbon dots in cancer theranostics are also highlighted.