DESMIN AND VIMENTIN AS MARKERS OF REGENERATION IN MUSCLE DISEASES
DESMIN AND VIMENTIN AS MARKERS OF REGENERATION IN MUSCLE DISEASES
复制标题
DOI：
10.1007/bf00304637
复制
发表时间：
1992-12-01
影响因子：
12.7
通讯作者：
SCARLATO, G
中科院分区：
文献类型：
--
作者：
GALLANTI, A;PRELLE, A;SCARLATO, G
利用单克隆抗体研究了不同神经肌肉疾病中desmin和vimentin的定位和分布。我们已经证明，尽管在正常的人类肌纤维中几乎不存在静脉蛋白，但在不同神经肌肉疾病的再生纤维中表达。此外，这些纤维显示强阳性的desmin抗体。在正常肌纤维中，desmin仅局限于z线水平。这些结果表明，desmin和vimentin可能在肌肉再生过程中过度表达，可能是因为它们在肌节结构组织中的重要性。
Localization and distribution of desmin and vimentin have been studied in different neuromuscular disorders using monoclonal antibodies. We have demonstrated that vimentin, although virtually absent in normal human muscle fibers, is expressed in regenerating fibers in different neuromuscular disorders. Moreover, these fibers showed a strong positivity with desmin antibodies. In normal muscle fibers desmin is only localized at Z-line level. These results suggest that desmin and vimentin may be over-expressed during muscle regeneration processes, probably because of their importance in the structural organization of the sarcomere.