Visual Modulation of Auditory Responses in the Owl Inferior Colliculus
Visual Modulation of Auditory Responses in the Owl Inferior Colliculus
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DOI：
10.1152/jn.91313.2008
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发表时间：
2009-06-01
影响因子：
2.5
通讯作者：
Knudsen, Eric I.
中科院分区：
文献类型：
--
作者：
Bergan, Joseph F.;Knudsen, Eric I.
柏根JF， Knudsen EI。猫头鹰下丘听觉反应的视觉调节。中国生物医学工程学报（英文版），2009。首次发表于2009年3月25日；doi: 10.1152 / jn.91313.2008。仓鸮的中央听觉系统在下丘外核（ICX）中创建了一个听觉空间图。虽然视觉经验在听觉空间图的形成和维持中起着至关重要的作用，但视觉影响ICX反应的机制仍不清楚。令人惊讶的是，先前的实验发现，在缺乏广泛的药物操作的情况下，视觉刺激不会驱动ICX的神经反应。本文研究了动态视觉刺激对ICX听觉反应的影响。我们发现，当一个显著的视觉刺激与一个听觉刺激同时出现时，可以调节ICX的听觉反应，即使同样的视觉刺激单独出现时可能不会引起神经反应。对于每个ICX神经元，最有效的听觉和视觉刺激位于空间的同一区域。此外，听觉反应的视觉调节的幅度取决于刺激呈现的背景，与频繁呈现的视觉刺激相比，新的视觉刺激会引起更大的反应调节。因此，ICX反应的视觉调节依赖于视觉刺激的特征以及听觉和视觉刺激的空间和时间对应。这些结果表明，听觉反应的即时视觉增强，在短期内增加了对显著双峰刺激的听觉反应，从长期来看，可能有助于指导维持准确听觉定向行为所必需的适应性听觉可塑性。
Bergan JF, Knudsen EI. Visual modulation of auditory responses in the owl inferior colliculus. J Neurophysiol 101: 2924-2933, 2009. First published March 25, 2009; doi: 10.1152/jn.91313.2008. The barn owl's central auditory system creates a map of auditory space in the external nucleus of the inferior colliculus (ICX). Although the crucial role visual experience plays in the formation and maintenance of this auditory space map is well established, the mechanism by which vision influences ICX responses remains unclear. Surprisingly, previous experiments have found that in the absence of extensive pharmacological manipulation, visual stimuli do not drive neural responses in the ICX. Here we investigated the influence of dynamic visual stimuli on auditory responses in the ICX. We show that a salient visual stimulus, when coincident with an auditory stimulus, can modulate auditory responses in the ICX even though the same visual stimulus may elicit no neural responses when presented alone. For each ICX neuron, the most effective auditory and visual stimuli were located in the same region of space. In addition, the magnitude of the visual modulation of auditory responses was dependent on the context of the stimulus presentation with novel visual stimuli eliciting consistently larger response modulations than frequently presented visual stimuli. Thus the visual modulation of ICX responses is dependent on the characteristics of the visual stimulus as well as on the spatial and temporal correspondence of the auditory and visual stimuli. These results demonstrate moment-to-moment visual enhancements of auditory responsiveness that, in the short-term, increase auditory responses to salient bimodal stimuli and in the long-term could serve to instruct the adaptive auditory plasticity necessary to maintain accurate auditory orienting behavior.