Guidance for Substantiating the Evidence for Beneficial Effects of Probiotics: Current Status and Recommendations for Future Research
Guidance for Substantiating the Evidence for Beneficial Effects of Probiotics: Current Status and Recommendations for Future Research
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DOI：
10.3945/jn.109.113779
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发表时间：
2010-03-01
影响因子：
4.2
通讯作者：
Antoine, Jean-Michel
中科院分区：
文献类型：
--
作者：
Rijkers, Ger T.;Bengmark, Stig;Antoine, Jean-Michel
益生菌是活的微生物，当给予足够的量时，对宿主的健康有益。科学界、消费者和食品行业对益生菌的兴趣日益浓厚。肠道和肠道微生物群之间以及常驻微生物群和瞬时微生物群之间的相互作用定义了生理学的一个新领域，对其的理解将揭示人类与微生物之间的“串扰”。特定益生菌菌株的不同有益效果可能转化为不同的健康声明。然而，有必要对益生菌和含益生菌的食品的特性和功效进行全面和统一的评估。ILSI的一个国际专家组评估了不同益生菌在4个（人类）应用领域的功能的已发表证据：7)代谢，2)慢性肠道炎症和功能障碍，3)感染和4)过敏。根据现有的证据，列出了具体的例子来证明益生菌的益处和差距，并确定了指导方针和建议，以帮助设计下一代益生菌研究。[j] .地理科学，2010(4):379 - 379。
Probiotic bacteria are live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. There is a growing interest in probiotics within the scientific community, with consumers, and in the food industry. The interactions between the gut and intestinal microbiota and between resident and transient microbiota define a new arena in physiology, an understanding of which would shed light on the "cross-talk" between humans and microbes. The different beneficial effects of specific probiotic strains may be translated into different health claims. However, there is a need for comprehensive and harmonized guidelines on the assessment of the characteristics and efficacy of probiotics and of foods containing them. An international expert group of ILSI has evaluated the published evidence of the functionality of different probiotics in 4 areas of (human) application: 7) metabolism, 2) chronic intestinal inflammatory and functional disorders, 3) infections, and 4) allergy. Based on the existing evidence, concrete examples of demonstration of benefits and gaps are listed, and guidelines and recommendations are defined that should help design the next generation of probiotic studies. J. Nutt. 140: 671S-676S, 2010.