IEDB and CEDAR: Two Sibling Databases to Serve the Global Scientific Community.
IEDB and CEDAR: Two Sibling Databases to Serve the Global Scientific Community.
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IEDB 和 CEDAR：为全球科学界服务的两个兄弟数据库。
DOI：
10.1007/978-1-0716-3239-0_9
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Sette,Alessandro
中科院分区：
文献类型：
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作者：
Blazeska,Nina;Kosaloglu-Yalcin,Zeynep;Vita,Randi;Peters,Bjoern;Sette,Alessandro
已经利用各种方法来分析在非自身抗原的情况下的表位特异性应答，例如与感染性疾病和过敏相关的那些，以及在自身抗原的情况下的表位特异性应答，例如与移植、自身免疫和癌症相关的那些。此外，表位特异性数据及其相关的免疫学背景对于训练和开发用于开发特定疫苗和诊断的预测算法和管道至关重要。在本章中，我们描述了用于获得两个兄弟资源的方法，免疫表位数据库（IEDB）和癌症表位数据库和分析资源（CEDAR），专门托管这些数据，并使其免费提供给科学界。
Various methodologies have been utilized to analyze epitope-specific responses in the context of non-self-antigens, such as those associated with infectious diseases and allergies, and in the context of self-antigens, such as those associated with transplantation, autoimmunity, and cancer. Further to this, epitope-specific data, and its associated immunological context, are crucial to training and developing predictive algorithms and pipelines for the development of specific vaccines and diagnostics. In this chapter, we describe the methodology utilized to derive two sibling resources, the Immune Epitope Database (IEDB) and Cancer Epitope Database and Analysis Resource (CEDAR), to specifically host this data, and make them freely available to the scientific community.