Tumor microenvironment: barrier or opportunity towards effective cancer therapy.
Tumor microenvironment: barrier or opportunity towards effective cancer therapy.
复制标题
肿瘤微环境：有效治疗癌症的障碍或机会。
DOI：
10.1186/s12929-022-00866-3
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发表时间：
2022-10-17
影响因子：
11
通讯作者：
Lin, Shiaw-Yih
中科院分区：
文献类型：
--
作者：
Tiwari, Aadhya;Trivedi, Rakesh;Lin, Shiaw-Yih
关键词：
肿瘤微环境(TME)是肿瘤细胞为肿瘤的成功发展和转移而设计的由宿主成分组成的专门生态系统。随着3D培养和先进的生物信息学方法的出现，现在有可能以更高的分辨率研究TME的各个组成部分及其相互作用。对免疫细胞的多样性、基质成分、谱系分析、新抗原预测的深入了解为探索免疫治疗干预的时空调控提供了机会。患者TME成分的变化在判断肿瘤免疫治疗有效和无效方面起着重要作用。因此，有可能对TME组件进行重新编程，以克服普遍存在的免疫治疗耐药性问题。本综述的重点是了解TME的复杂性，并了解其成分作为潜在治疗靶点的未来前景。综述的后半部分描述了作为研究TME成分的有价值的手段而出现的复杂的3D模型，并广泛地介绍了先进的生物信息学工具来分析TME成分和预测新的抗原。总体而言，本综述全面介绍了针对TME的现有知识。
Tumor microenvironment (TME) is a specialized ecosystem of host components, designed by tumor cells for successful development and metastasis of tumor. With the advent of 3D culture and advanced bioinformatic methodologies, it is now possible to study TME’s individual components and their interplay at higher resolution. Deeper understanding of the immune cell’s diversity, stromal constituents, repertoire profiling, neoantigen prediction of TMEs has provided the opportunity to explore the spatial and temporal regulation of immune therapeutic interventions. The variation of TME composition among patients plays an important role in determining responders and non-responders towards cancer immunotherapy. Therefore, there could be a possibility of reprogramming of TME components to overcome the widely prevailing issue of immunotherapeutic resistance. The focus of the present review is to understand the complexity of TME and comprehending future perspective of its components as potential therapeutic targets. The later part of the review describes the sophisticated 3D models emerging as valuable means to study TME components and an extensive account of advanced bioinformatic tools to profile TME components and predict neoantigens. Overall, this review provides a comprehensive account of the current knowledge available to target TME.
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影响因子：
46.9
作者：
Becht, Etienne;McInnes, Leland;Newell, Evan W.
通讯作者：
Newell, Evan W.
DOI：
10.1016/j.mattod.2015.05.002
发表时间：
2015-12
期刊：
Materials today (Kidlington, England)
影响因子：
--
作者：
Asghar W;El Assal R;Shafiee H;Pitteri S;Paulmurugan R;Demirci U
通讯作者：
Demirci U
影响因子：
9.3
作者：
Baron M;Veres A;Wolock SL;Faust AL;Gaujoux R;Vetere A;Ryu JH;Wagner BK;Shen-Orr SS;Klein AM;Melton DA;Yanai I
通讯作者：
Yanai I
影响因子：
19
作者：
Ackerman, Daniel;Simon, M. Celeste
通讯作者：
Simon, M. Celeste
影响因子：
64.5
作者：
Cancer Genome Atlas Research Network
通讯作者：
Cancer Genome Atlas Research Network