Relationships between the luteinizing hormone surge and other characteristics of the menstrual cycle in normally ovulating women
Relationships between the luteinizing hormone surge and other characteristics of the menstrual cycle in normally ovulating women
复制标题
DOI：
10.1016/j.fertnstert.2012.08.047
复制
发表时间：
2013-01-01
影响因子：
6.7
通讯作者：
Ecochard, Rene
中科院分区：
文献类型：
--
作者：
Direito, Ana;Bailly, Sebastien;Ecochard, Rene
目的：描述排卵期女性黄体生成素激增变异，并分析其与排卵期及其他激素水平的关系。设计：前瞻性队列观察研究的二次分析。设置：8个自然计划生育诊所。对象：正常生育的妇女（n - 107）超过283个周期。干预措施：妇女收集每天早晨的尿液，绘制基础体温和宫颈粘液排出图，并进行卵巢超声检查。主要观察指标：尿LH、FSH、雌酮-3-葡糖苷（E3G）、孕二醇-3- α -葡糖苷（PDG）、超声促排卵天数（US-DO）。结果：个别LH浪涌在形态、幅度和持续时间上变化很大。该研究还表明，有几个峰值的LH激增与破裂前卵泡大小较小和排卵当天LH水平较低有统计学意义。排卵后持续3天的LH激增与排卵前E3G较低、排卵后2天黄体较小、排卵后前4天PDG值较低有关。结论：在临床实践中，LH谱应与正常生育周期中观察到的谱范围进行比较，而不是与平均谱进行比较。肥料(R) 2013；99: 279 - 85。(C) 2013年由美国生殖医学学会出版。)
Objective: To describe the LH surge variants in ovulating women and analyze their relationship with the day of ovulation and other hormone levels.Design: Secondary analysis of a prospective cohort observational study.Setting: Eight natural family planning clinics.Subjects: Normally fertile women (n - 107) over 283 cycles.Intervention(s): Women collected daily first morning urine, charted basal body temperature and cervical mucus discharge, and underwent serial ovarian ultrasound.Main Outcome Measure(s): Urinary LH, FSH, estrone-3-glucuronide (E3G), pregnanediol-3 alpha-glucuronide (PDG), and day of ovulation by ultrasound (US-DO).Result(s): Individual LH surges were extremely variable in configuration, amplitude, and duration. The study also showed that LH surges marked by several peaks were associated with statistically significant smaller follicle sizes before rupture and lower LH level on the day of ovulation. LH surges lasting >3 days after ovulation were associated with a lower E3G before ovulation, a smaller corpus luteum 2 days after ovulation, and a lower PDG value during the first 4 days after ovulation.Conclusion(s): In clinical practice, LH profiles should be compared with the range of profiles observed in normally fertile cycles, not with the mean profile. (Fertil Steril (R) 2013; 99: 279-85. (C) 2013 by American Society for Reproductive Medicine.)