Chronic cocaine reduces RGS4 mRNA in rat prefrontal cortex and dorsal striatum.
Chronic cocaine reduces RGS4 mRNA in rat prefrontal cortex and dorsal striatum.
复制标题
慢性可卡因会降低大鼠前额皮质和背侧纹状体中的 RGS4 mRNA。
DOI：
10.1097/wnr.0b013e328240507a
复制
发表时间：
2007
期刊：
影响因子：
1.7
通讯作者：
McGinty,JacquelineF
中科院分区：
文献类型：
--
作者：
Schwendt,Marek;Hearing,MatthewC;See,RonaldE;McGinty,JacquelineF
Neuroadaptations affecting dopamine transmission within the prefrontal cortex and striatum are thought to underlie relapse to cocaine seeking after extended periods of abstinence. Regulator of G-protein signaling 4 (RGS4) is a forebrain-enriched protein known to be dynamically regulated by dopamine receptors in response to acute psychostimulant administration. In this report, chronic noncontingent (cocaine binge) or response-contingent (self-administration) delivery of cocaine followed by 2–3 weeks of abstinence resulted in a decrease of RGS4 mRNA in the dorsal striatum and prefrontal cortex. Furthermore, re-exposure to the cocaine-associated context after abstinence renewed the drug seeking and restored the levels of RGS4 mRNA to control values. Changes in RGS4 mRNA levels might signal abnormal receptor G-protein coupling that impacts cocaine seeking.
