Controlled comparison of buspirone and clomipramine in obsessive-compulsive disorder.
Controlled comparison of buspirone and clomipramine in obsessive-compulsive disorder.
复制标题
丁螺环酮和氯米帕明治疗强迫症的对照比较。
DOI：
10.1176/ajp.148.1.127
复制
发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Murphy,DL
中科院分区：
文献类型：
--
作者：
Pato,MT;Pigott,TA;Hill,JL;Grover,GN;Bernstein,S;Murphy,DL
在一项双盲随机分配研究中，18名强迫症患者接受丁螺环酮(一种部分5-羟色胺激动剂)或氯丙咪嗪(一种5-羟色胺摄取抑制剂)治疗。这两种药物在耶鲁-布朗强迫症评定量表以及其他强迫症和抑郁量表上的得分都有统计上的显著改善和相似的改善。这一初步结果值得在更大的样本和其他5-羟色胺能药物上进一步探索。
Eighteen outpatients with obsessive-compulsive disorder were treated with either buspirone, a partial serotonin agonist, or clomipramine, a serotonin uptake inhibitor, in a double-blind, random-assignment study. Both drugs led to statistically significant and similar improvements in scores on the Yale-Brown Obsessive-Compulsive Rating Scale and other obsessive-compulsive and depression scales. This preliminary result warrants further exploration with a larger sample and other serotonergic agents.