LncRNA Gas5 regulates Fn1 deposition via Creb5 in renal fibrosis
LncRNA Gas5 regulates Fn1 deposition via Creb5 in renal fibrosis
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LncRNA Gas5 通过 Creb5 调节肾纤维化中的 Fn1 沉积
DOI：
10.2217/epi-2020-0449
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发表时间：
2021-04-20
期刊：
影响因子：
3.8
通讯作者：
Wang, Lijing
中科院分区：
文献类型：
--
作者：
Su, Huanhou;Xie, Jingzhou;Wang, Lijing
目的：尽管lncRNA在肾纤维化中的研究主要集中在lncRNA的靶基因和功能上，但缺乏对lncRNA相互作用的全面分析。材料与方法：筛选肾纤维化差异表达基因，并寻找lncRNAs和miRNAs之间的相互作用。结果如下：我们构建了一个与肾纤维化相关的ceRNA网络，通过这个网络我们发现了一个转录因子Creb 5，它是lncRNA Gas 5的一个靶基因，可能调节细胞外Fn1沉积。结论：本研究不仅为Gas5的ceRNA调控机制提供了理论依据，也为Gas5靶向治疗肾纤维化提供了实验依据。
Aim: Although studies on lncRNAs in renal fibrosis have focused on target genes and functions of lncRNAs, a comprehensive interaction analysis of lncRNAs is lacking. Materials & methods: Differentially expressed genes in renal fibrosis were screened, and the interaction between lncRNAs and miRNAs was searched. Results: We constructed a ceRNA network associated with renal fibrosis, by which we found the transcription factor Creb5, a target gene of lncRNA Gas5 that might regulate extracellular Fn1 deposition. Conclusion: Our study not only provides a theoretical basis for the ceRNA regulation mechanism of Gas5 but also provides experimental evidence supporting the use of Gas5 targeting in the treatment of renal fibrosis.