18F-fluoromethylcholine (FCho), 18F-fluoroethyltyrosine (FET), and 18F-fluorodeoxyglucose (FDG) for the discrimination between high-grade glioma and radiation necrosis in rats: A PET study
18F-fluoromethylcholine (FCho), 18F-fluoroethyltyrosine (FET), and 18F-fluorodeoxyglucose (FDG) for the discrimination between high-grade glioma and radiation necrosis in rats: A PET study
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DOI：
10.1016/j.nucmedbio.2014.07.006
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发表时间：
2015-01-01
影响因子：
3.1
通讯作者：
Goethals, Ingeborg
中科院分区：
文献类型：
--
作者：
Bolcaen, Julie;Descamps, Benedicte;Goethals, Ingeborg
前言：鉴别(高级别)脑肿瘤复发和放射性坏死(RN)仍然是一个诊断挑战，因为这两个实体在常规磁共振成像(MRI)上具有相似的成像特征。代谢成像，如正电子发射断层扫描(PET)，可以克服这一诊断困境。本研究探讨了2-[F-18]-氟-2-脱氧-D-葡萄糖(F-18-FDG)、O-(2-[F-18]-氟乙基)-L酪氨酸(F-18-FET)和[F-18]-Fluoromethyl-dimethyl-2-hydroxyethylammonium(F-18-氟甲基胆碱，F-18-FCho)正电子发射计算机断层扫描在鉴别高级别肿瘤和肾癌中的作用。右额叶采用3道弧形照射，照射剂量60Gy3×3 mm(n=3)。用F-18-FDG、F-18-FET和F-18-FCho进行动态PET成像，并在延迟时间间隔(240 mm后)进行F-18-FDG PET扫描。结果：MRI在接种后15天显示增强的肿瘤(n=4)，在照射后5-6个月显示增强的RN病变(n=3)。在F-18-FDGPET上，GB组的平均皮损/正常比(LNR均值)显著高于RN组(p=0.034)。在晚期的F-18-FDG PET图像上，肿瘤和RN之间的LNR平均值的差异高于从最后一次动态采集时间帧(这是在传统的时间间隔)重建的PET图像。F-18-FCho PET测得的LNR在GB和RN之间无显著差异(p=1.000)。在F-18-FETPET上，GB的LNR平均值显著高于RN(p=0.034)。结论：与F-18-FCHO不同，F-18-FDG和F-18-FETPET对区分GB和RN是有效的。有趣的是，在F-18-FDG的情况下，延迟PET似乎特别有用。知识的进步和对患者护理的启示：我们的结果表明，(延迟的)F-18-FDG和F-18-FET PET可用于区分GB(复发)和RN(复发)。这些结果需要在临床研究中得到证实。(C)2014 Elsevier Inc.保留所有权利。
Introduction: Discrimination between (high-grade) brain tumor recurrence and radiation necrosis (RN) remains a diagnostic challenge because both entities have similar imaging characteristics on conventional magnetic resonance imaging (MRI). Metabolic imaging, such as positron emission tomography (PET) could overcome this diagnostic dilemma. In this study, we investigated the potential of 2-[F-18]-fluoro-2-deoxy-D-glucose (F-18-FDG), O-(2-[F-18]-fluoroethyl)-L-tyrosine (F-18-FET), and [F-18]-Fluoromethyl-dimethyl-2-hydroxyethylammonium (F-18-fluoromethylcholine, F-18-FCho) PET in discriminating high-grade tumor from RN.Methods: We developed a glioblastoma (GB) rat model by inoculating F98 GB cells into the right frontal region. Induction of RN was achieved by irradiating the right frontal region with 60 Gy using three arcs with a beam aperture of 3 x 3 mm (n = 3). Dynamic PET imaging with F-18-FDG, F-18-FET, and F-18-FCho, as well as F-18-FDG PET at a delayed time interval (240 mm postinjection), was acquired.Results: MRI revealed contrast-enhancing tumors at 15 days after inoculation (n = 4) and contrast-enhancing RN lesions 5-6 months postirradiation (n = 3). On F-18-FDG PET, the mean lesion-to-normal ratio (LNRmean) was significantly higher in GB than in RN (p = 0.034). The difference in the LNRmean between tumors and RN was higher on the late F-18-FDG PET images than on the PET images reconstructed from the last time frame of the dynamic acquisition (this is at a conventional time interval). LNRs obtained from F-18-FCho PET were not significantly different between GB and RN (p = 1.000). On F-18-FET PET, the LNRmean was significantly higher in GB compared to RN (p = 0.034).Conclusions: Unlike F-18-FCho, F-18-FDG and F-18-FET PET were effective in discriminating GB from RN. Interestingly, in the case of F-18-FDG, delayed PET seems particularly useful.Advances in knowledge and implications for patient care: Our results suggest that (delayed) F-18-FDG and F-18-FET PET can be used to discriminate GB (recurrence) from RN. Confirmation of these results in clinical studies is needed. (C) 2014 Elsevier Inc. All rights reserved.