Asymmetric control of food intake by left and right vagal sensory neurons.
Asymmetric control of food intake by left and right vagal sensory neurons.
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DOI：
10.1101/2023.05.08.539627
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发表时间：
2023-05-08
期刊：
影响因子：
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通讯作者：
de Lartigue G
中科院分区：
文献类型：
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作者：
de Araujo AM;Braga I;Leme G;Singh A;McDougle M;Smith J;Vergara M;Yang M;Lin M;Khoshbouei H;Krause E;de Oliveira AG;de Lartigue G
我们研究了肠道神经迷走神经感觉神经元的偏侧化及其在进食行为中的作用。通过遗传、解剖和行为分析，我们发现了一组高度偏侧化的迷走神经感觉神经元，对肠道刺激具有不同的感觉反应。我们的结果表明，左迷走神经感觉神经元（LNG）对于扩张引起的饱腹感至关重要，而右迷走神经感觉神经元（RNG）则介导对营养食物的偏好。此外，这些侧化神经元参与不同的中枢回路，LNG 神经元招募与能量平衡相关的大脑区域，RNG 神经元激活与显着性、记忆和奖励相关的区域。总而言之，我们的研究结果揭示了不对称肠道-迷走神经-大脑回路在进食行为中的不同作用，为代谢和神经精神疾病中针对迷走神经刺激的潜在治疗干预措施提供了新的见解。偏侧化的肠脑回路对不同的感觉方式做出反应并控制不同的进食行为。
We investigated the lateralization of gut-innervating vagal sensory neurons and their roles in feeding behavior. Using genetic, anatomical, and behavioral analyses, we discovered a subset of highly lateralized vagal sensory neurons with distinct sensory responses to intestinal stimuli. Our results demonstrated that left vagal sensory neurons (LNG) are crucial for distension-induced satiety, while right vagal sensory neurons (RNG) mediate preference for nutritive foods. Furthermore, these lateralized neurons engage different central circuits, with LNG neurons recruiting brain regions associated with energy balance and RNG neurons activating areas related to salience, memory, and reward. Altogether, our findings unveil the diverse roles of asymmetrical gut-vagal-brain circuits in feeding behavior, offering new insights for potential therapeutic interventions targeting vagal nerve stimulation in metabolic and neuropsychiatric diseases. Lateralized gut-brain circuits respond to different sensory modalities and control distinct feeding behaviors.