Novelty seeking and reward dependence-related large-scale brain networks functional connectivity variation during salience expectancy
Novelty seeking and reward dependence-related large-scale brain networks functional connectivity variation during salience expectancy
复制标题
新颖性寻求和奖励依赖相关的大规模大脑网络功能连接在显着性预期期间的变化
DOI：
10.1002/hbm.23648
复制
发表时间：
2017-08-01
影响因子：
4.8
通讯作者：
Walter, Martin
中科院分区：
文献类型：
--
作者：
Li, Shijia;Demenescu, Liliana Ramona;Walter, Martin
显著性网络（SN）锚定在脑岛前部（AI）和背前扣带皮层（dACC）中，在显著性检测和注意调节过程中，在大脑网络之间的切换中起着关键作用。以往的fMRI研究将期望行为和SN激活与新奇寻求（NS）和奖励依赖（RD）人格特征联系起来。为了探讨生理期的功能连通性（FC）是如何被内部（期望相关）显著性分配和不同的人格特质调节的，68名健康参与者使用功能磁共振成像完成了显著性期望任务，并进行了心理生理相互作用分析（PPI）来确定在这些预期期间显著性相关连通性的变化。然后利用32名男性参与者的气质和性格量表来评估PPI与人格特征之间的相关性。在高显著性预期期间，sn种子区域对视觉区域和部分默认模式网络的FC减少，但对中央执行网络的FC增加。随着NS的增加，受试者在期待高显著性图像时，右侧AI和中扣带皮层之间的连接明显增加，而在期待高显著性图像时，RD的增加也预示着右侧dACC和尾状核皮层的减少。我们的研究结果表明人格特质与内部显著性加工之间存在直接联系，这种联系是由SN的差异网络整合介导的。因此，SN活动和协调可能受到寻求新奇和奖励依赖的人格特征的调节，这与成瘾风险有关。中国生物医学工程学报（英文版），2017。(c) 2017 Wiley期刊公司
A salience network (SN) anchored in the anterior insula (AI) and dorsal anterior cingulate cortex (dACC) plays a key role in switching between brain networks during salience detection and attention regulation. Previous fMRI studies have associated expectancy behaviors and SN activation with novelty seeking (NS) and reward dependence (RD) personality traits. To address the question of how functional connectivity (FC) in the SN is modulated by internal (expectancy-related) salience assignment and different personality traits, 68 healthy participants performed a salience expectancy task using functional magnetic resonance imaging, and psychophysiological interaction analysis (PPI) was conducted to determine salience-related connectivity changes during these anticipation periods. Correlation was then evaluated between PPI and personality traits, assessed using the temperament and character inventory of 32 male participants. During high salience expectancy, SN-seed regions showed reduced FC to visual areas and parts of the default mode network, but increased FC to the central executive network. With increasing NS, participants showed significantly increasing disconnection between right AI and middle cingulate cortex when expecting high-salience pictures as compared to low-salience pictures, while increased RD also predicted decreased right dACC and caudate FC for high salience expectancy. Our findings suggest a direct link between personality traits and internal salience processing mediated by differential network integration of the SN. SN activity and coordination may therefore be moderated by novelty seeking and reward dependency personality traits, which are associated with risk of addiction. Hum Brain Mapp 38:4064-4077, 2017. (c) 2017 Wiley Periodicals, Inc.