Cardiovascular Complications Associated With Primary Aldosteronism: A Controlled Cross-Sectional Study
Cardiovascular Complications Associated With Primary Aldosteronism: A Controlled Cross-Sectional Study
复制标题
DOI：
10.1161/hypertensionaha.113.01060
复制
发表时间：
2013-08-01
期刊：
影响因子：
8.3
通讯作者：
Steichen, Olivier
中科院分区：
文献类型：
--
作者：
Savard, Sebastien;Amar, Laurence;Steichen, Olivier
据报道，原发性醛固酮增多症（PA）患者发生心血管事件的风险高于其他相似的原发性高血压（EH）患者。然而，证据受到样本量小和潜在混杂因素的限制。因此，我们比较了2001年至2006年在我们的高血压科诊断的459例PA患者和1290例EH对照组的心血管事件患病率。PA病例和EH对照在性别、年龄（+/- 2岁）和诊室收缩压（+/- 10 mmHg）方面单独匹配。PA组与EH组在高血压病程、血钾、血浆醛固酮、血浆肾素浓度、醛固酮/肾素比值、尿醛固酮浓度等方面差异有统计学意义（P
A higher risk of cardiovascular events has been reported in patients with primary aldosteronism (PA) than in otherwise similar patients with essential hypertension (EH). However, the evidence is limited by small sample size and potential confounding factors. We, therefore, compared the prevalence of cardiovascular events in 459 patients with PA diagnosed in our hypertension unit from 2001 to 2006 and 1290 controls with EH. PA cases and EH controls were individually matched for sex, age (+/- 2 years), and office systolic blood pressure (+/- 10 mmHg). Patients with PA and EH differed significantly in duration of hypertension, serum potassium, plasma aldosterone and plasma renin concentrations, aldosterone-to-renin ratio, and urinary aldosterone concentration (P