A New Mutant in the Progeny of Mice Treated with Nitrogen Mustard
A New Mutant in the Progeny of Mice Treated with Nitrogen Mustard
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DOI：
10.1038/163678a0
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发表时间：
1949-04
期刊：
影响因子：
64.8
通讯作者：
C. Auerbach;D. Falconer
中科院分区：
文献类型：
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作者：
C. Auerbach;D. Falconer
芥末化合物诱导基因突变和染色体重排的能力是在对果蝇1-3进行的实验中首次检测到的。随后的研究表明，这种能力延伸到了所有到目前为止已经测试过的生物：神经孢子菌4、紫露菌5、青霉菌6、大麦7、细菌8和蚕豆9。毫无疑问，芥子的诱变能力和X射线一样普遍。另一方面，没有优先理由假设应用于其他生物的芥末会表现出与在对果蝇的工作中发现的相同的遗传效应的特点，即相对缺乏大的重排2，推迟作用10，11，以及优先作用于未成熟的精子12。
THE ability of the mustard compounds to induce gene mutations and chromosome re-arrangements was first detected in experiments withDrosophila melanogaster1–3. Subsequent investigators showed that this ability extends to all organisms which so far have been tested :Neurospora4,Tradescantia5,Penicillium6, barley7, bacteria8andVicia9. There can be little doubt that the mutagenic ability of the mustards is as general as that of X-rays. On the other hand, there is noa priorireason for assuming that mustards applied to other organisms will exhibit the same peculiarities of genetical effect which have been found in the work withDrosophila, namely, a relative shortage of large re-arrangements2, deferred action10,11, and preferential action on immature sperm12.