Age-dependent association of apolipoprotein E genotype with coronary and aortic atherosclerosis in middle-aged men -: An autopsy study
Age-dependent association of apolipoprotein E genotype with coronary and aortic atherosclerosis in middle-aged men -: An autopsy study
复制标题
DOI：
10.1161/01.cir.100.6.608
复制
发表时间：
1999-08-10
期刊：
影响因子：
37.8
通讯作者：
Karhunen, PJ
中科院分区：
文献类型：
--
作者：
Ilveskoski, E;Perola, M;Karhunen, PJ
Background-Apolipoprotein E (apoE) polymorphism is one of the genetic determinants of serum cholesterol values, The apoE epsilon 4 allele has been associated with advanced coronary heart disease (CHD) diagnosed by angiography, but the role of the apoE genotype in atherosclerosis has not been confirmed at vessel-wall level, nor is any age-dependent effect of the apoE genotype on the development of CHD known.Methods and Results-The right and left anterior descending coronary arteries (RCA and LAD) and the aorta from 700 male autopsy cases (Helsinki Sudden Death Study) in 1981-1982 and 1991-1992 (average age 53 years, range 33 to 70 years) were stained for fat, and all areas covered with fatty streaks, fibrotic plaques, and complicated lesions were measured, In the RCA and LAD, the apoE genotype was significantly associated with the area of total atherosclerotic lesions in men
