HIGH-LEVEL EXPRESSION OF HEPATITIS-B VIRAL-ANTIGENS IN FIBROSING CHOLESTATIC HEPATITIS
HIGH-LEVEL EXPRESSION OF HEPATITIS-B VIRAL-ANTIGENS IN FIBROSING CHOLESTATIC HEPATITIS
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DOI：
10.1016/0016-5085(92)90182-x
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发表时间：
1992-03-01
期刊：
影响因子：
29.4
通讯作者：
WILLIAMS, R
中科院分区：
文献类型：
--
作者：
LAU, JYN;BAIN, VG;WILLIAMS, R
对4例纤维化淤胆型肝炎（FCH）移植受者的肝组织中B型肝炎病毒抗原的表达进行定量，并与5例未发生该综合征的其他移植受者和30例慢性B型肝炎病毒（HBV）感染患者进行比较。用放射免疫分析法测定，FCH患者肝组织中的B型肝炎表面抗原（HBsAg）和核衣壳抗原的含量均显著高于无FCH的移植患者（P< 0.01）或慢性HBV感染患者（P< 0.001）。FCH中pre-S1/pre-S2的肝内表达也很广泛，其分布与HBsAg平行。肝内HBsAg和B型肝炎核心抗原在移植肝中的高水平表达与移植肝中FCH的后续发展相关，表明病毒/宿主因素也可能是重要的。通过与Chisari的转基因小鼠模型和Roingeard的HBV转染的HepG 2细胞模型类比，这种肝内肝炎病毒抗原表达模式可能是这种情况下直接肝细胞病变损伤的原因。
The expression of hepatitis B viral antigens was quantified in liver tissue from four transplant recipients with fibrosing cholestatic hepatitis (FCH) and compared with five other transplant recipients who did not develop this syndrome and 30 patients with chronic hepatitis B virus (HBV) infection. As measured by radioimmunoassays, the liver tissue from patients with FCH had significantly greater amounts of both hepatitis B surface antigen (HBsAg) and nucleocapsid antigens than to transplant patients without this syndrome (P< 0.01) or patients with chronic HBV infection (P< 0.001). Intrahepatic expression of pre-S1/pre-S2in FCH was also extensive with a distribution parallel to that of HBsAg. High-level expression of intrahepatic HBsAg and hepatitis B core antigen in the explanted liver was associated with subsequent development of FCH in the liver graft, suggesting that viral/host factors may also be important. This pattern of intrahepatic hepatitis viral antigen expression, by analogy with Chisari's transgenic mice model and Roingeard's HBV-transfected HepG2 cell model, may be the cause of direct hepatocytopathic injury in this condition.