Dietary intakes of fat and risk of Parkinson's disease
Dietary intakes of fat and risk of Parkinson's disease
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DOI：
10.1093/aje/kwg073
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发表时间：
2003-06-01
影响因子：
5
通讯作者：
Ascherio, A
中科院分区：
文献类型：
--
作者：
Chen, H;Zhang, SMM;Ascherio, A
以前的流行病学研究对脂肪摄入量与帕金森病风险之间的关系得出了不一致的结果。作者在美国的两个大型前瞻性队列中调查了这些关联。在随访期间，他们记录了191例男性帕金森病（1986-1998）和168例女性帕金森病（1980-1998）。总的来说，总脂肪或主要类型脂肪的摄入量与风险没有显著关联。在男性中，动物脂肪摄入量最高的五分位数与最低的五分位数相比的相对风险为1.42(95%可信区间（CI）： 0.91, 2.20；p为趋势= 0.1)，女性为0.65 （95% CI: 0.36, 1.16； p为趋势= 0.3）。对于男性，而不是女性，用饱和脂肪替代多不饱和脂肪与显著增加的风险相关（5%的能量摄入，相对风险(R) = 1.83, 95% CI: 1.10, 3.03）。在单个多不饱和脂肪酸中，花生四烯酸倾向于与风险呈负相关（极端五分位数之间的合并FIR = 0.65, 95% CI: 0.46, 0.91；趋势p = 0.05）。研究结果不支持总脂肪摄入量在帕金森病发病机制中的重要作用，但不能排除饱和脂肪对男性的可能不利影响。
Previous epidemiologic studies have generated inconsistent results regarding the associations between fat intakes and risk of Parkinson's disease. The authors investigated these associations in two large, prospective US cohorts. They documented 191 incident cases of Parkinson's disease in men (1986-1998) and 168 in women (1980-1998) during the follow-up. Overall, intakes of total fat or major types of fat were not significantly associated with the risk. The relative risks comparing the highest quintile of animal fat intake with the lowest were 1.42 for men (95% confidence interval (CI): 0.91, 2.20; p for trend = 0.1) and 0.65 for women (95% CI: 0.36, 1.16; p for trend = 0.3). For men, but not women, replacement of polyunsaturated fat with saturated fat was associated with a significantly increased risk (5% of energy intake, relative risk (R) = 1.83, 95% CI: 1.10, 3.03). Of the individual polyunsaturated fatty acids, arachidonic acid tended to be inversely associated with the risk (pooled' FIR between extreme quintiles = 0.65, 95% CI: 0.46, 0.91; p for trend = .05). Results do not support an important role of overall fat intake in the pathogenesis of Parkinson's disease, but a possible adverse effect of saturated fat for men could not be excluded.