Why do couples drop-out from IVF treatment? A prospective cohort study
Why do couples drop-out from IVF treatment? A prospective cohort study
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DOI：
10.1093/humrep/den219
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发表时间：
2008-09-01
影响因子：
6.1
通讯作者：
Macklon, N. S.
中科院分区：
文献类型：
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作者：
Verberg, M. F. G.;Eijkemans, M. J. C.;Macklon, N. S.
背景：累积IVF妊娠率受到大量夫妇在妊娠前退出治疗的影响。本研究的目的是确定所应用的治疗策略的作用，以及影响夫妇停止治疗决定的其他潜在因素。方法：在年龄50%的IVF患者队列中研究了WIT治疗的脱落率和脱落相关因素。严重男性生育力低下（HR 4.80; 95% CI，1.63-14.13）和未能实现胚胎移植（比值比0.41; 95% CI，0.24-0.72）也与脱落相关。结论：降低脱落率是进一步提高IVF治疗效果和成本效益的关键。决定辍学风险的一个重要因素是治疗策略的负担。温和治疗策略的应用和管理患者的期望可能会降低辍学率。
BACKGROUND: Cumulative IVF pregnancy rates are compromised by the large number of couples who drop-out of treatment before achieving pregnancy. The aim of this study was to identify the role of the treatment strategy applied, and potential other factors that influence the decision of couples to discontinue treatment. METHODS: The incidence of drop-out from WIT treatment and factors related to drop-out were studied in a cohort of IVF patients aged 50%. The presence of severe male subfertility (HR 4.80; 95% CI, 1.63-14.13) and the failure to achieve embryo transfer (odds ratio 0.41; 95% CI, 0.24-0.72) were also related to drop-out. CONCLUSIONS: Reducing drop-out rate is crucial to further improve the efficacy and cost-effectiveness of IVF treatment. An important factor determining the risk of drop-out is the burden of the treatment strategy. The application of a mild treatment strategy and managing patient's expectations might reduce drop-out rates.