HIV-1 reverse transcription.
HIV-1 reverse transcription.
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DOI：
10.1101/cshperspect.a006882
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发表时间：
2012-10-01
影响因子：
5.4
通讯作者：
Hughes, Stephen H
中科院分区：
文献类型：
--
作者：
Hu, Wei-Shau;Hughes, Stephen H
逆转录和整合是逆转录病毒科的定义特征;通用名称“逆转录病毒”源自这些病毒使用病毒编码的酶逆转录酶（RT）将其RNA基因组转化为DNA的事实。逆转录是逆转录病毒复制的重要步骤。本文介绍了逆转录的概述，简要介绍了RT的结构和功能，提供了一些细胞和病毒的因素，可以影响逆转录的介绍，并讨论保真度和重组，逆转录中发挥重要作用的两个过程。为了与收藏的主题保持一致，重点是HIV-1和HIV-1 RT。
Reverse transcription and integration are the defining features of the Retroviridae; the common name "retrovirus" derives from the fact that these viruses use a virally encoded enzyme, reverse transcriptase (RT), to convert their RNA genomes into DNA. Reverse transcription is an essential step in retroviral replication. This article presents an overview of reverse transcription, briefly describes the structure and function of RT, provides an introduction to some of the cellular and viral factors that can affect reverse transcription, and discusses fidelity and recombination, two processes in which reverse transcription plays an important role. In keeping with the theme of the collection, the emphasis is on HIV-1 and HIV-1 RT.