CYP1B1 variants are associated with prostate cancer in non-Hispanic and Hispanic Caucasians.
CYP1B1 variants are associated with prostate cancer in non-Hispanic and Hispanic Caucasians.
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DOI：
10.1093/carcin/bgm300
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发表时间：
2008-09
期刊：
影响因子：
4.7
通讯作者：
Leach RJ
中科院分区：
文献类型：
--
作者：
Beuten J;Gelfond JA;Byrne JJ;Balic I;Crandall AC;Johnson-Pais TL;Thompson IM;Price DK;Leach RJ
细胞色素P450 1B 1（CYP 1B 1）参与许多致癌物质的活化和类固醇激素的代谢。我们比较了非西班牙裔高加索人（496例和498例对照）和西班牙裔高加索人（153例和240例对照）中CYP 1B 1内6个单核苷酸多态性（SNP）的等位基因、基因型和单倍型频率。在西班牙裔白人中，与CC基因型相比，rs 1056836 GG基因型降低了前列腺癌（PCa）的风险[比值比（OR）= 0.31，P = 0.04，95%置信区间（CI）= 0.10-0.96]。在非西班牙裔白人男性中，更积极的PCa，几个SNP（rs 2567206，rs 2551188，rs 2617266，rs 10012和rs 1056836）的患病率与疾病状态显着相关。一种常见的C-G-C-C-G-A单倍型rs 2567206-rs 2551188-rs 2617266-rs 10012-rs 1056836-rs 1800440与西班牙裔白人前列腺癌风险呈负相关（OR = 0.19，P = 0.04，95%CI = 0.04-0.95）和侵袭性疾病状态（即Gleason评分≥7）（OR = 0.64，P = 0.008，95%CI = 0.47-0.89）。在非西班牙裔白人病例中，第二个主要单倍型T-A-T-G-C-A与高级别疾病状态正相关（OR = 1.77，P = 0.002，95%CI = 1.24-2.53）。我们的研究结果表明，CYP 1B 1的遗传多态性可能会改变前列腺癌的风险，并支持CYP 1B 1作为前列腺癌的候选基因的作用。
Cytochrome P450 1B1 (CYP1B1) is involved in the activation of many carcinogens and in the metabolism of steroid hormones. We compared allele, genotype and haplotype frequencies of six single-nucleotide polymorphisms (SNPs) within CYP1B1 among non-Hispanic Caucasians (496 cases and 498 controls) and Hispanic Caucasians (153 cases and 240 controls). In the Hispanic Caucasians, the GG genotype for rs1056836 decreased the risk for prostate cancer (PCa) when compared with the CC genotype [odds ratio (OR) = 0.31, P = 0.04, 95% confidence interval (CI) = 0.10–0.96]. Among non-Hispanic Caucasian men with more aggressive PCa, the prevalence of several SNPs (rs2567206, rs2551188, rs2617266, rs10012 and rs1056836) was significantly associated with the disease status. A common C-G-C-C-G-A haplotype for rs2567206-rs2551188-rs2617266-rs10012-rs1056836-rs1800440 showed an inverse association with PCa risk in Hispanic Caucasians (OR = 0.19, P = 0.04, 95% CI = 0.04–0.95) and with aggressive disease status (i.e. Gleason score ≥7) in non-Hispanic Caucasian cases (OR = 0.64, P = 0.008, 95% CI = 0.47–0.89). In the non-Hispanic Caucasian cases, a second major haplotype T-A-T-G-C-A was positively associated with the high-grade disease status (OR = 1.77, P = 0.002, 95% CI = 1.24–2.53). Our findings suggest that genetic polymorphisms in CYP1B1 may modify the risk for PCa and support the role of CYP1B1 as a candidate gene for PCa.
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