Early life manipulations of vasopressin-family peptides alter vocal learning
Early life manipulations of vasopressin-family peptides alter vocal learning
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DOI：
10.1098/rspb.2017.1114
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发表时间：
2017-07-26
影响因子：
4.7
通讯作者：
Adkins-Regan, Elizabeth
中科院分区：
文献类型：
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作者：
Baran, Nicole M.;Peck, Samantha C.;Adkins-Regan, Elizabeth
从社会伙伴那里学习声音对许多物种成功发展交流至关重要。社会互动组织注意力并增强学习物种典型行为的动机。然而，连接社会动机和声乐学习的神经生物学机制尚不清楚。利用斑马雀（Taeniopygia guttata），一种普遍存在的声乐学习模型，我们表明，在发育早期操纵后叶加压素家族（精氨酸后叶催产素，AVT）中的非肽类激素可以促进或破坏鸣叫和社交动机。年轻的雄性斑胸草雀和人类婴儿一样，喜欢社交，需要成人导师的互动反馈来学习成熟的声音形式。为了研究社会动机机制在鸣叫学习中的作用，在两项研究中，我们在孵化后2-8天注射了AVT或Manning化合物（MC，一种非肽受体拮抗剂），并在成熟时记录鸣叫。在这两项研究中，MC雄性对导师歌曲的匹配度都不如对照组。在实验控制了导师和遗传因素的研究2中，AVT雄性对歌曲的学习也明显优于对照组。此外，在整个发展过程中，歌曲相似性与若干社会动机指标相关。这些发现提供了第一个证据，证明非肽对声音学习的发展至关重要。
Vocal learning from social partners is crucial for the successful development of communication in a wide range of species. Social interactions organize attention and enhance motivation to learn species-typical behaviour. However, the neurobiological mechanisms connecting social motivation and vocal learning are unknown. Using zebra finches (Taeniopygia guttata), a ubiquitous model for vocal learning, we show that manipulations of nonapeptide hormones in the vasopressin family (arginine vasotocin, AVT) early in development can promote or disrupt both song and social motivation. Young male zebra finches, like human infants, are socially gregarious and require interactive feedback from adult tutors to learn mature vocal forms. To investigate the role of social motivational mechanisms in song learning, in two studies, we injected hatchling males with AVT or Manning compound (MC, a nonapeptide receptor antagonist) on days 2-8 post-hatching and recorded song at maturity. In both studies, MC males produced a worse match to tutor song than controls. In study 2, which experimentally controlled for tutor and genetic factors, AVT males also learned song significantly better compared with controls. Furthermore, song similarity correlated with several measures of social motivation throughout development. These findings provide the first evidence that nonapeptides are critical to the development of vocal learning.