Proposed animal model of severe Parkinson's disease: neonatal 6-hydroxydopamine lesion of dopaminergic innervation of striatum.
Proposed animal model of severe Parkinson's disease: neonatal 6-hydroxydopamine lesion of dopaminergic innervation of striatum.
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拟议的严重帕金森病动物模型：纹状体多巴胺能神经支配的新生儿 6-羟基多巴胺损伤。
DOI：
10.1007/978-3-211-45295-0_43
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Nowak,P
中科院分区：
文献类型：
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作者：
Kostrzewa,RM;Kostrzewa,JP;Brus,R;Kostrzewa,RA;Nowak,P
出生后不久用6-羟基多巴胺损伤的大鼠被认为是一种近乎理想的严重帕金森病模型，因为该过程的非致死性，黑质纹状体多巴胺能纤维的几乎完全破坏，纹状体的几乎完全多巴胺（DA）去神经支配，效果的可重复性，以及相对缺乏明显的行为效应-没有失语症，没有厌食症，运动活动没有变化。体内微透析研究结果加强了动物模型的实用性，清楚地证明了左旋多巴的有益作用，而不增加羟基自由基的产生。
Rats lesioned shortly after birth with 6-hydroxydopamine are posed as a near-ideal model of severe Parkinson’s disease, because of the non-lethality of the procedure, near-total destruction of nigrostriatal dopaminergic fibers, near-total dopamine (DA)-denervation of striatum, reproducibility of effect, and relative absence of overt behavioral effects–there is no aphasia, no adipsia, and no change in motor activity. In vivo microdialysis findings reinforce the utility of the animal model, clearly demonstrating L-DOPA beneficial actions without an increase in hydroxyl radical production.