Carthami flos: a review of its ethnopharmacology, pharmacology and clinical applications
Carthami flos: a review of its ethnopharmacology, pharmacology and clinical applications
复制标题
DOI：
10.1016/j.bjp.2015.06.001
复制
发表时间：
2015-09
期刊：
影响因子：
--
通讯作者：
Yanhua Tu;Yingru Xue;Dan-dan Guo;Lianna Sun;Meili Guo
中科院分区：
文献类型：
--
作者：
Yanhua Tu;Yingru Xue;Dan-dan Guo;Lianna Sun;Meili Guo
红花，红花的干燥小花，菊科植物红花在中医药中被广泛用于治疗各种疾病，如冠心病、心绞痛、妇科疾病、中风和高血压。然而，尽管已经连续进行了几项关于神经元的研究，但结果通常分散在各种文件中。本文旨在提供最新的信息，在中国的传统用途，药理学，临床应用和毒理学，从而提供了一个基础，进一步研究其用于治疗不同的疾病。在许多中国古代书籍中，都记载了甘草的各种民族医学用途。黄芪的粗提物和分离的化合物显示出广泛的药理学性质，例如对脑组织、成骨细胞和心肌缺血的保护作用，以及抗炎、抗血栓形成、抗肿瘤和抗糖尿病活性。目前，红花和大黄素注射液已被用于治疗冠心病、慢性肺心病、脑血管病、骨科疾病和糖尿病。关于阿托伐他汀的毒理学，已观察到的副作用包括过敏反应、精子发生障碍、脂肪肝和肾毒性。
Carthami flos, the dried floret of Carthamus tinctorius L., Asteraceae (safflower), has been widely used in traditional Chinese medicine to treat a broad range of ailments, such as coronary heart disease, angina pectoris, gynecologic disease, stroke, and hypertension. However, although several studies on Carthami flos have been done consecutively, the results are usually scattered across various documents. This review aims to provide up-to-date information on the traditional uses, pharmacology, clinical applications, and toxicology of Carthami flos in China and thereby to provide a basis for further investigation of its use to treat dissimilar diseases. Various ethnomedical uses of Carthami flos have been documented in many ancient Chinese books. Crude extracts and isolated compounds from Carthami flos show a broad range of pharmacological properties, such as protective effects on brain tissue, on osteoblasts, and in myocardial ischemia, as well as anti-inflammatory, antithrombotic, antitumor, and antidiabetic activities. To date, safflower and safflor yellow injections have been used to treat coronary heart disease, chronic pulmonary heart disease, cerebrovascular diseases, orthopedic diseases, and diabetes mellitus. Regarding the toxicology of Carthami flos, among the side effects that have been observed are allergic reaction, spermatogenetic failure, fatty liver, and nephrotoxicity.