Developmentally regulated selective autophagy determines ER inheritance by gametes.
Developmentally regulated selective autophagy determines ER inheritance by gametes.
复制标题
发育调控的选择性自噬决定配子的内质网遗传。
DOI：
10.1080/15548627.2022.2040315
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发表时间：
2022
期刊：
影响因子：
13.3
通讯作者：
Brar,GloriaAnn
中科院分区：
文献类型：
--
作者：
Otto,GeorgeMaxwell;Brar,GloriaAnn
内质网（ER）执行从蛋白质运输到代谢物信号传导的基本细胞功能。ER功能部分通过质量控制途径维持，包括在细胞应激条件下通过选择性自噬（网状吞噬）降解ER。已知网状吞噬对于细胞对饥饿和蛋白质折叠应激的反应是重要的，但在发育期间没有确定自然作用。在芽殖酵母减数分裂的保守细胞分化过程中研究ER重塑时，我们意外地观察到由自噬受体Atg 40的表达驱动的发育调节的网状吞噬。这种网状吞噬与ER的大量形态学重排相协调，包括大多数皮质ER远离细胞外周的运动。由于减数分裂网状细胞吞噬阻止特定的ER亚群被配子遗传，我们建议它起质量控制作用，防止有害物质传递给后代。
The endoplasmic reticulum (ER) carries out essential cellular functions ranging from protein trafficking to metabolite signaling. ER function is maintained in part by quality control pathways including ER degradation by selective autophagy (reticulophagy) during conditions of cellular stress. Reticulophagy is known to be important for cellular responses to starvation and protein folding stress, but no natural role during development had been identified. While investigating ER remodeling during the conserved cell differentiation process of meiosis in budding yeast, we unexpectedly observed developmentally regulated reticulophagy that was driven by expression of the autophagy receptor Atg40. This reticulophagy was coordinated with massive morphological rearrangement of the ER, including movement of most cortical ER away from the cell periphery. As meiotic reticulophagy prevents specific ER subpopulations from being inherited by gametes, we propose that it serves a quality control role, preventing deleterious material from being passed on to subsequent generations.