Fibroblast growth factors: Activities and significance of non-neurotrophin neurotrophic growth factors
Fibroblast growth factors: Activities and significance of non-neurotrophin neurotrophic growth factors
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DOI：
10.1016/0959-4388(94)90035-3
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发表时间：
1994-01-01
影响因子：
5.7
通讯作者：
Baird, Andrew
中科院分区：
文献类型：
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作者：
Baird, Andrew
虽然成纤维细胞生长因子最初的特征是在体外刺激内皮细胞增殖和在体内刺激血管生成，但现在也充分认识到它们的神经营养活性。然而，了解这些多功能、几乎无处不在和多能性分子的生理意义仍然是个谜。最近的进展，描述了他们的分子，生物化学和生物学特性，导致更好地了解他们在中枢神经系统中的作用。
Although first characterized by virtue of their ability to stimulate endothelial cell proliferationin vitroand angiogenesisin vivo, the fibroblast growth factors are now also well recognized for their neurotrophic activities. Understanding the physiological significance of these multifunctional, virtually ubiquitous and pluripotential molecules, however, remains enigmatic. Recent advances describing their molecular, biochemical and biological characteristics has led to a better understanding of their role in the central nervous system.