The Philippine cynomolgus monkey (Macaca fascicularis) provides a new nonhuman primate model of tuberculosis that resembles human disease
The Philippine cynomolgus monkey (Macaca fascicularis) provides a new nonhuman primate model of tuberculosis that resembles human disease
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DOI：
10.1038/nm0496-430
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发表时间：
1996-04-01
期刊：
影响因子：
82.9
通讯作者：
Horwitz, MA
中科院分区：
文献类型：
--
作者：
Walsh, GP;Tan, EV;Horwitz, MA
迫切需要一种与人类疾病非常相似的非人类灵长类结核病模型。我们已经将菲律宾食蟹猴作为结核病的模型进行了评估。用极高剂量的结核分枝杆菌(10(5)或10(4)CFU)经气管内攻击食蟹猴，可发展为急性、快速进展、高致死性的多叶性肺炎。然而，受到中或低剂量结核分枝杆菌(小于或等于10(3)CFU)挑战的猴子会发展成一种慢性、缓慢进展的局限性肺结核，类似于人类的疾病，经常伴随着眼部结核、脑膜炎和结核性脊柱炎等临床症状。接受10(2)或10(1)CFU挑战的猴子中，相当大比例的人感染处于亚临床状态。菲律宾食蟹猴模型是慢性结核病的优秀模型，为在动物模型中研究亚临床和潜在的潜在疾病提供了机会。
A nonhuman primate model of tuberculosis that closely resembles human disease is urgently needed. We have evaluated the Philippine cynomolgus monkey, Macaca fasicularis, as a model of TB. Cynomolgus monkeys challenged intratracheally with extremely high doses of Mycobocterium tuberculosis (10(5) or 10(4) CFU) developed an acute, rapidly progressive, highly fatal multilobar pneumonia. However, monkeys challenged with moderate or low doses of M. tuberculosis (less than or equal to 10(3) CFU) developed a chronic, slowly progressive, localized form of pulmonary TB, akin to the disease in humans, that was frequently accompanied by such clinical syndromes as ocular tuberculosis, meningitis and tuberculous spondylitis. A significant proportion of monkeys challenged with 10(2) or 10(1) CFU contained the infection in a subclinical state. The Philippine cynomolgus monkey model is an excellent model of chronic TB and provides an opportunity to study subclinical and potentially latent disease in an animal model.