Dissolved core alginate microspheres as "smart-tattoo" glucose sensors.
Dissolved core alginate microspheres as "smart-tattoo" glucose sensors.
复制标题
溶解的核心藻酸盐微球作为“智能纹身”葡萄糖传感器。
DOI：
10.1109/iembs.2009.5334597
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Srivastava,Rohit
中科院分区：
文献类型：
--
作者：
Chaudhary,Ayesha;Raina,Monica;McShane,MichaelJ;Srivastava,Rohit
The feasibility of multilayer thin film coated dissolved-core alginate-templated microsphere sensors based on fluorescence resonance energy transfer and competitive binding, was explored in simulated interstitial fluid, using glucose as a model analyte. The glucose sensitivity was observed to be 0.89%/mM glucose with a linear response in the range of 0-50 mM glucose. The sensor response was observed to be completely reversible in nature with a response time of 120 seconds. The system was further demonstrated to respond similarly using near-infrared dyes (Alexa Fluor-647-labeled dextran as donor and QSY-21-conjugated apo-GOx as acceptor) which exhibited a sensitivity of 0.94%/mM glucose with a linear response in range of 0-50 mM glucose, making the sensor more amenable to in vivo use, when implanted in scattering tissue.
