Intra-and Inter-Network Functional Alterations in Parkinson's Disease with Mild Cognitive Impairment
Intra-and Inter-Network Functional Alterations in Parkinson's Disease with Mild Cognitive Impairment
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DOI：
10.1002/hbm.23499
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发表时间：
2017-03-01
影响因子：
4.8
通讯作者：
Taylor, John-Paul
中科院分区：
文献类型：
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作者：
Peraza, Luis R.;Nesbitt, David;Taylor, John-Paul
轻度认知障碍(MCI)在确诊的帕金森病(PD)患者中占15%-40%。在这项研究中，我们研究了最近诊断的PD患者在静息状态功能磁共振成像(RS-fMRI)中的脑内和网络间变化，并将他们描述为认知正常(PD-NC)或MCI(PD-MCI)。将患者分为PD-NC组(N562)和PD-MCI组(N537)，并与健康对照组(HC、N530)进行比较。从26个静息状态网络(RSN)的参与者的rsfMRI中调查了网络内和网络间的连通性。在与运动控制(运动皮质)、空间注意力和视觉感知相关的网络方面，两组患者和HCS之间的网络内差异被发现。当比较PD-NC和PD-MCI时，在与注意力、执行功能和运动控制(小脑)相关的RSN中发现了网络内的变化。网络间分析显示，与HCS相比，PD-NC患者的基底节网络和运动皮质之间存在超同步。当两组患者进行比较时，发现了与注意力、运动控制、视觉感知和执行功能相关的RSN的网络内变化。与HCS相比，我们还在两组患者中检测到了疾病驱动的负同步以及从阳性到阴性的同步转变，反之亦然。PD患者基底节和运动皮质RSNs的超同步化及其由负向正的同步化与HCS相比，提示PD患者静息状态脑内对基础功能障碍的代偿性反应和改变的基底-皮质运动控制。(C)2017威利期刊公司。
Mild cognitive impairment (MCI) is prevalent in 15%-40% of Parkinson's disease (PD) patients at diagnosis. In this investigation, we study brain intra- and inter-network alterations in resting state functional magnetic resonance imaging (rs-fMRI) in recently diagnosed PD patients and characterise them as either cognitive normal (PD-NC) or with MCI (PD-MCI). Patients were divided into two groups, PD-NC (N562) and PD- MCI (N537) and for comparison, healthy controls (HC, N530) were also included. Intra- and inter-network connectivity were investigated from participants' rsfMRIs in 26 resting state networks (RSNs). Intra-network differences were found between both patient groups and HCs for networks associated with motor control (motor cortex), spatial attention and visual perception. When comparing both PD-NC and PD-MCI, intra-network alterations were found in RSNs related to attention, executive function and motor control (cerebellum). The inter-network analysis revealed a hyper-synchronisation between the basal ganglia network and the motor cortex in PD-NC compared with HCs. When both patient groups were compared, intra-network alterations in RSNs related to attention, motor control, visual perception and executive function were found. We also detected disease-driven negative synchronisations and synchronisation shifts from positive to negative and vice versa in both patient groups compared with HCs. The hyper-synchronisation between basal ganglia and motor cortical RSNs in PD and its synchronisation shift from negative to positive compared with HCs, suggest a compensatory response to basal dysfunction and altered basal-cortical motor control in the resting state brain of PD patients. (C) 2017 Wiley Periodicals, Inc.