Mechanisms of neuroprotection during ischemic preconditioning: Lessons from anoxic tolerance
Mechanisms of neuroprotection during ischemic preconditioning: Lessons from anoxic tolerance
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DOI：
10.1016/j.cbpa.2006.08.032
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发表时间：
2007-06-01
影响因子：
2.3
通讯作者：
Perez-Pinzon, Miguel A.
中科院分区：
文献类型：
--
作者：
Perez-Pinzon, Miguel A.
动物界已经描述了抗缺氧的不同生理适应。这些适应对于心脏和大脑等极易受到能量剥夺的器官尤其重要。在脊椎动物中，龟是耐缺氧能力很强的物种之一。然而，在哺乳动物中，缺氧、缺血和低血糖等损伤都会对大脑造成重大的组织病理学事件。然而，在哺乳动物中，当在诱导致死性缺血/缺氧损伤之前的某个时间诱导亚致死性缺血/缺氧损伤时，甚至发现局部缺血或缺氧耐受。这种现象被定义为缺血预处理。更好地了解诱导海龟耐缺氧或哺乳动物缺血预处理的机制可能会提供新的治疗干预措施，帮助哺乳动物大脑抵抗脑缺血的破坏。在这篇综述中，我们将总结两种耐受模型中实施的一些机制，强调生理和生化的相似性。 (c) 2006 Elsevier Inc. 保留所有权利。
Different physiological adaptations for anoxia resistance have been described in the animal kingdom. These adaptations are particularly important in organs that are highly susceptible to energy deprivation such as the heart and brain. Among vertebrates, turtles are one of the species that are highly tolerant to anoxia. In mammals however, insults such as anoxia, ischemia and hypoglycemia, all cause major histopathological events to the brain. However, in mammals even ischemic or anoxic tolerance is found when a sublethal ischemic/anoxic insult is induced sometime before a lethal ischemic/anoxic insult is induced. This phenomenon is defined as ischemic preconditioning. Better understanding of the mechanisms inducing both anoxic tolerance in turtles or ischemic preconditioning in mammals may provide novel therapeutic interventions that may aide mammalian brain to resist the ravages of cerebral ischemia. In this review, we will summarize some of the mechanisms implemented in both models of tolerance, emphasizing physiological and biochemical similarities. (c) 2006 Elsevier Inc. All rights reserved.