Isoflavone intake and risk of lung cancer: a prospective cohort study in Japan
Isoflavone intake and risk of lung cancer: a prospective cohort study in Japan
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DOI：
10.3945/ajcn.2009.28161
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发表时间：
2010-03-01
影响因子：
7.1
通讯作者：
Tsugane, Shoichiro
中科院分区：
文献类型：
--
作者：
Shimazu, Taichi;Inoue, Manami;Tsugane, Shoichiro
背景：尽管病例对照研究支持大豆食物或异黄酮类食物的摄入与肺癌风险降低相关的观点，但从前瞻性队列研究中几乎没有证据可用。目的：我们调查了异黄酮类摄入量与肺癌发病率之间的关系。设计：我们在1995-1999年进行了一项以人群为基础的前瞻性队列研究，研究对象为年龄在45-74岁之间、没有癌症病史的36,177名男性和40,484名女性。参与者回答了一份有效的问卷，其中包括138种食物。结果：在11年(671,864人年)的随访中，我们记录了481例男性和178例女性肺癌病例。在男性中，我们发现从不吸烟者的异黄酮类摄入量与肺癌风险呈负相关(n=13,051；与异黄酮类摄入量最低的四分位数相比，多变量心率最高者：0.43；95%CI：0.21，0.90；趋势图中的P=0.024)，但在现在或过去吸烟者中没有。在从不吸烟的女性中也发现了类似的、不显著的负关联(n=38,211；HR：0.67；95%CI：0.41，1.10；趋势P=0.135)。我们还测试了吸烟状态对效果的影响(交互作用P=男性0.085，男性和女性加在一起为0.055)。结论：在日本一项大规模的基于人群的前瞻性研究中，异黄酮类摄入量与从不吸烟的人患肺癌的风险降低有关。AM J Clin Nutr 2010；91：722-8。
Background: Although case-control studies support the idea that soy foods or isoflavone intake is associated with a decreased risk of lung cancer, little evidence is available from prospective cohort studies. Moreover, no prospective study has addressed this association in men.Objective: We investigated the association between isoflavone intake and lung cancer incidence.Design: We conducted a population-based prospective cohort study in 36,177 men and 40,484 women aged 45-74 y with no history of cancer at baseline in 1995-1999. Participants responded to a validated questionnaire, which included 138 food items. We used Cox proportional hazards regression analysis to estimate the hazard ratios (HRs) and 95% CIs of lung cancer incidence according to isoflavone intake, which was estimated by genistein content from soy foods.Results: During 11 y (671,864 person-years) of follow-up, we documented 481 male and 178 female lung cancer cases. In men we found an inverse association between isoflavone intake and risk of lung cancer in never smokers (n = 13,051; multivariate HR in the highest compared with the lowest quartile of isoflavone intake: 0.43; 95% CI: 0.21, 0.90; P for trend = 0.024) but not in current or past smokers. A similar, nonsignificant inverse association was seen in never-smoking women ( n = 38,211; HR: 0.67; 95% CI: 0.41, 1.10; P for trend = 0.135). We also tested effect modification by smoking status (P for interaction = 0.085 in men and 0.055 in men and women combined).Conclusion: In a large-scale, population-based, prospective study in Japan, isoflavone intake was associated with a decreased risk of lung cancer in never smokers. Am J Clin Nutr 2010; 91: 722-8.