Effects of benzalkonium chloride upon the corneal epithelium studied with scanning electron microscopy.
Effects of benzalkonium chloride upon the corneal epithelium studied with scanning electron microscopy.
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用扫描电子显微镜研究苯扎氯铵对角膜上皮的影响。
DOI：
10.1111/j.1755-3768.1975.tb01167.x
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发表时间：
2009
影响因子：
3.4
通讯作者：
A. Tønjum
中科院分区：
文献类型：
--
作者：
A. Tønjum
本文用扫描电镜观察了阳离子表面活性剂苯扎氯铵对兔和猕猴角膜表面的影响。药物浓度为0.02%或0.01%，暴露时间为2或4分钟。用药物处理的角膜具有特征性变化，表面细胞膜的小孔或更广泛的损伤，以及微绒毛或微皱褶的丢失。认为损伤是由于苯扎氯铵对质膜的溶解作用所致。
The corneal surface of rabbits and vervet monkeys was studied by means of scanning electron microscopy after the influence of the cationic surfactant, benzalkonium chloride. The concentration of the drug was 0.02% or 0.01% and the exposure time was 2 or 4 min. The corneas treated with the drug had characteristic changes with small holes or more extensive lesions of the superficial cell membranes, and loss of microvilli or microplicae. The damage was considered to be due to the lytic effect of benzalkonium chloride upon the plasma membranes.