Hemochromatosis: 1980 update.
Hemochromatosis: 1980 update.
复制标题
血色素沉着症：1980 年更新。
DOI：
10.1016/0016-5085(80)90592-2
复制
发表时间：
1980
期刊：
影响因子：
29.4
通讯作者：
J. Halliday
中科院分区：
文献类型：
--
作者：
L. Powell;M. Bassett;J. Halliday
在过去的十年中，在铁的生物学知识和由体内铁代谢异常引起的临床疾病方面取得了重大进展。这些进展包括：(a)铁储存和运输的主要蛋白质，铁蛋白和转铁蛋白的结构和功能方面；(b)铁毒性可能机制的新概念；(c)早期发现和管理缺铁和铁超载；(d)澄清特发性血色素沉着症（IHC）的遗传性质。这篇综述主要致力于肝脏在铁代谢和铁储存疾病中的作用，以及血色素沉着病的最新进展。
During the past decade there have been major advances in the knowledge of the biology of iron and of clinical disorders resulting from abnormalities in body iron metabolism. These advances include:(a) structural and functional aspects of the major proteins of iron storage and transport, ferritin, and transferrin;(b) new concepts of the possible mechanisms of iron toxicity;(c) the early detection and management of iron deficiency and iron overload; and (d) clarification of the genetic nature of idiopathic hemochromatosis(IHC). This review is devoted primarily to the role of the liver in iron metabolism and iron-storage diseases, and to the major recent advances in the knowledge of hemochromatosis.