Synergistic Effect: Hydroalkoxylation of Allenes through Combination of Enantiopure BIPHEP-Gold Complexes and Chiral Anions
Synergistic Effect: Hydroalkoxylation of Allenes through Combination of Enantiopure BIPHEP-Gold Complexes and Chiral Anions
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DOI：
10.1002/adsc.201000672
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发表时间：
2010-12-17
影响因子：
5.4
通讯作者：
Mikami, Koichi
中科院分区：
文献类型：
--
作者：
Aikawa, Kohsuke;Kojima, Masafumi;Mikami, Koichi
研究了中性双核金配合物与手性磷酸银配合物在联烯分子内烷氧基化反应中的协同效应，得到了高产率和高选择性的呋喃衍生物.单阳离子双核金配合物比中性或双阳离子双核金配合物具有更高的催化活性和对映选择性。因此，协同效应非常有希望为设计有效的手性环境以产生不对称催化剂提供指导原则。
A synergistic effect is observed for the combination of a neutral dinuclear gold complex with a chiral silver phosphate in the intramolecular hyroalkoxylation of allenes to give furan derivatives in high yields and enantioselectivities. The monocationic dinuclear gold complex affords higher catalytic activity and enantioselectivity than the neutral or dicationic digold complexes. The synergistic effect is thus highly promising to provide a guiding principle in designing an efficient chiral environment for creating an asymmetric catalyst.